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fcp1 RNA polymerase II CTD phosphatase Fcp1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542225, updated on 18-Sep-2024

Summary

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Official Symbol
fcp1
Official Full Name
RNA polymerase II CTD phosphatase Fcp1
Primary source
PomBase:SPAC19B12.05c
Locus tag
SPOM_SPAC19B12.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See fcp1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003424.3 (4890740..4893628, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene cell wall 1,3-beta-glucan synthase catalytic subunit Bgs3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS30 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene zinc finger protein Neighboring gene ncRNA Neighboring gene rhomboid family protease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Schizosaccharomyces pombe carboxyl-terminal domain (CTD) phosphatase Fcp1: distributive mechanism, minimal CTD substrate, and active site mapping. Hausmann S, et al. J Biol Chem, 2004 Mar 19. PMID 14701811
  2. Characterization of the CTD phosphatase Fcp1 from fission yeast. Preferential dephosphorylation of serine 2 versus serine 5. Hausmann S, et al. J Biol Chem, 2002 Jun 14. PMID 11934898
  3. The structure of Fcp1, an essential RNA polymerase II CTD phosphatase. Ghosh A, et al. Mol Cell, 2008 Nov 21. PMID 19026779, Free PMC Article
  4. Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1. Schwer B, et al. RNA, 2015 Jun. PMID 25883047, Free PMC Article
  5. A cyclin-dependent kinase that promotes cytokinesis through modulating phosphorylation of the carboxy terminal domain of the RNA Pol II Rpb1p sub-unit. Karagiannis J, et al. PLoS One, 2007 May 9. PMID 17502918, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in signaling NAS
Non-traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
RNA polymerase II CTD phosphatase Fcp1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4890740..4893628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020195.3 → NP_594768.1  RNA polymerase II CTD phosphatase Fcp1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594768.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9P376
    Conserved Domains (3) summary
    TIGR02250
    Location:159 → 318
    FCP1_euk; FCP1-like phosphatase, phosphatase domain
    COG5190
    Location:139 → 609
    FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]
    cl00038
    Location:510 → 561
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
Nucleotide Protein
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