U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

prp19 Prp19 complex subunit, ubiquitin-protein ligase E4 Prp19 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542256, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
prp19
Official Full Name
Prp19 complex subunit, ubiquitin-protein ligase E4 Prp19
Primary source
PomBase:SPAC29A4.08c
Locus tag
SPOM_SPAC29A4.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
cwf8
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See prp19 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (5133223..5135342)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene rRNA exonuclease Rrp17 Neighboring gene ncRNA Neighboring gene mediator complex subunit Med22 Neighboring gene splicing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene myosin I light chain Cam2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural and functional analysis of essential pre-mRNA splicing factor Prp19p. Ohi MD, et al. Mol Cell Biol, 2005 Jan. PMID 15601865, Free PMC Article
  2. The Prp19 WD40 domain contains a conserved protein interaction region essential for its function. Vander Kooi CW, et al. Structure, 2010 May 12. PMID 20462492, Free PMC Article
  3. Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation. Mikolaskova B, et al. Int J Mol Sci, 2021 Jun 29. PMID 34209806, Free PMC Article
  4. Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing. McDonald WH, et al. Mol Cell Biol, 1999 Aug. PMID 10409726, Free PMC Article
  5. Interacting factors and cellular localization of SR protein-specific kinase Dsk1. Tang Z, et al. Exp Cell Res, 2012 Oct 1. PMID 22683458

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA cis splicing, via spliceosome EXP
Inferred from Experiment
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Prp19 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nuclear envelope HDA PubMed 
is_active_in nucleus HDA PubMed 
part_of post-mRNA release spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Prp19 complex subunit, ubiquitin-protein ligase E4 Prp19

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5133223..5135342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020303.3 → NP_594874.1  Prp19 complex subunit, ubiquitin-protein ligase E4 Prp19 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594874.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14011
    Conserved Domains (4) summary
    sd00039
    Location:252 → 293
    7WD40; WD40 repeat [structural motif]
    cd16656
    Location:2 → 54
    RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
    pfam08606
    Location:67 → 131
    Prp19; Prp19/Pso4-like
    cl29593
    Location:237 → 434
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous