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ysh1 cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542258, updated on 18-Sep-2024

Summary

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Official Symbol
ysh1
Official Full Name
cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1
Primary source
PomBase:SPAC17G6.16c
Locus tag
SPOM_SPAC17G6.16C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ysh1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003424.3 (3620761..3623710, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TREX complex subunit, ATP-dependent RNA helicase Uap56 Neighboring gene ncRNA Neighboring gene sideroflexin Fsf1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LARP7 family RNA-binding protein Pof8/Lar7 Neighboring gene protein Rqc1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA. Wittmann S, et al. Nat Commun, 2017 Apr 3. PMID 28367989, Free PMC Article
  2. CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing. Vo TV, et al. Cell Rep, 2019 Jul 2. PMID 31269446, Free PMC Article
  3. A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Roguev A, et al. Mol Cell Proteomics, 2004 Feb. PMID 14617822
  4. The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection. Lemay JF, et al. Genes Dev, 2016 Jul 1. PMID 27401558, Free PMC Article
  5. CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation. Vanoosthuyse V, et al. PLoS Genet, 2014 Jun. PMID 24945319, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 5'-3' RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3620761..3623710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019686.3 → NP_594263.2  cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594263.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13794
    Conserved Domains (5) summary
    smart01027
    Location:253 → 374
    Beta-Casp; Beta-Casp domain
    COG1236
    Location:19 → 462
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:387 → 427
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    pfam11718
    Location:484 → 650
    CPSF73-100_C; Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
    cd16292
    Location:19 → 212
    CPSF3-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; MBL-fold metallo-hydrolase domain
Nucleotide Protein
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