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ras1 GTPase Ras1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542285, updated on 18-Sep-2024

Summary

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Official Symbol
ras1
Official Full Name
GTPase Ras1
Primary source
PomBase:SPAC17H9.09c
Locus tag
SPOM_SPAC17H9.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
ste5
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Genomic context

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See ras1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (2019462..2020631, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene signal recognition particle subunit Srp21 Neighboring gene ncRNA Neighboring gene coenzyme A transporter Neighboring gene ncRNA Neighboring gene protein Ddb1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ras1 function of Schizosaccharomyces pombe mediates pheromone-induced transcription. Nielsen O, et al. EMBO J, 1992 Apr. PMID 1563351, Free PMC Article
  2. Quantitative analysis of human ras localization and function in the fission yeast Schizosaccharomyces pombe. Bond M, et al. Yeast, 2013 Apr. PMID 23447405
  3. Biochemical similarity of Schizosaccharomyces pombe ras1 protein with RAS2 protein of Saccharomyces cervisiae. Onozawa T, et al. Yeast, 1995 Jul. PMID 7483844
  4. sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Wang Y, et al. Cell Regul, 1991 Jun. PMID 1883874, Free PMC Article
  5. Homologous activators of ras in fission and budding yeast. Hughes DA, et al. Nature, 1990 Mar 22. PMID 2107403

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ras1 activity was restricted by the guanosine triphosphatase-activating protein Gap1, which was itself recruited to sites of Ras1-GTP and was essential to block untimely fusion attempts.
    Title: Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating.
  2. Data indicate that sp-Erf2/zDHHC9 palmitoylates Ras proteins in a highly selective manner in the trans-Golgi compartment to facilitate PM targeting via the trans-Golgi network, a role that is most certainly critical for Ras-driven tumorigenesis.
    Title: Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.
  3. Data show that Ras1 signaling is compartment-specific and indicate that spatial specificity in the Ras pathway is evolutionarily conserved.
    Title: Compartmentalized signaling of Ras in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables CTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activator activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mating projection assembly EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of mating projection assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of pheromone response MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction involved in positive regulation of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cdc42 GTPase complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cell cortex of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cortical dynamic polarity patch IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mating projection actin fusion focus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GTPase Ras1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2019462..2020631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019011.3 → NP_593579.1  GTPase Ras1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593579.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13806, P08647
    Conserved Domains (2) summary
    cd04138
    Location:8 → 170
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    smart00010
    Location:7 → 172
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
Nucleotide Protein
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