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Ctsc cathepsin C [ Rattus norvegicus (Norway rat) ]

Gene ID: 25423, updated on 25-Apr-2024

Summary

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Official Symbol
Ctscprovided by RGD
Official Full Name
cathepsin Cprovided by RGD
Primary source
RGD:2445
See related
Ensembl:ENSRNOG00000016496 AllianceGenome:RGD:2445
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CATC; DPPI; DPP-I
Summary
Enables several functions, including chaperone binding activity; chloride ion binding activity; and identical protein binding activity. Involved in several processes, including aging; positive regulation of proteolysis involved in cellular protein catabolic process; and proteolysis. Located in Golgi apparatus; endoplasmic reticulum; and lysosome. Biomarker of brain ischemia; hypertension; and obesity. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 604.8), Kidney (RPKM 269.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ctsc in Genome Data Viewer
Location:
1q32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (151440860..151472430)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (142028386..142059841)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (151918514..151949979)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 5 Neighboring gene eukaryotic translation initiation factor 5, pseudogene 5 Neighboring gene uncharacterized LOC102554680 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RAB38, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia. Audzeyenka I, et al. Biochim Biophys Acta Mol Cell Res, 2020 Aug. PMID 32302668
  2. The regulatory role of Dipeptidyl peptidase I on the activation of immune granulocytes. Chu Y, et al. Cell Biol Int, 2017 Oct. PMID 28665049
  3. Genomics of the periinfarction cortex after focal cerebral ischemia. Lu A, et al. J Cereb Blood Flow Metab, 2003 Jul. PMID 12843783
  4. Importance of the propeptide in the biosynthetic maturation of rat cathepsin C. Santilman V, et al. Eur J Cell Biol, 2002 Dec. PMID 12553666
  5. Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain. Olsen JG, et al. FEBS Lett, 2001 Oct 12. PMID 11602245

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cathepsin C Regulates Cytokine-Induced Apoptosis in beta-Cell Model Systems.
    Title: Cathepsin C Regulates Cytokine-Induced Apoptosis in β-Cell Model Systems.
  2. Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia.
    Title: Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia.
  3. Findings demonstrate the role of DPPI in regulating MCs and NPs activation, and modulating proteolysis in the process of RA.
    Title: The regulatory role of Dipeptidyl peptidase I on the activation of immune granulocytes.
  4. Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.
    Title: Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloride ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables dipeptidyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidase activator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of microglial cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteolysis involved in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis TAS
Traceable Author Statement
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dipeptidyl peptidase 1
Names
cathepsin J
dipeptidyl peptidase I
dipeptidyl transferase
NP_058793.1
XP_008757859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017097.2 → NP_058793.1  dipeptidyl peptidase 1 precursor

    See identical proteins and their annotated locations for NP_058793.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P80067, P80068
    UniProtKB/TrEMBL
    A6I5Z1
    Related
    ENSRNOP00000022342.3, ENSRNOT00000022342.6
    Conserved Domains (3) summary
    cd02621
    Location:230 → 459
    Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...
    cl28439
    Location:168 → 204
    Pox_I6; Poxvirus I6-like family
    pfam08773
    Location:25 → 138
    CathepsinC_exc; Cathepsin C exclusion domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    151440860..151472430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759637.4 → XP_008757859.1  dipeptidyl peptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_008757859.1

    UniProtKB/TrEMBL
    A0A8I5ZZG1, A0A8I6A0Q1, A6I5Z3
    Related
    ENSRNOP00000085136.1
    Conserved Domains (1) summary
    pfam08773
    Location:26 → 106
    CathepsinC_exc; Cathepsin C exclusion domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80067.3 GenPept UniProtKB/Swiss-Prot:P80067

Gene LinkOut

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