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cdt2 WD repeat protein Cdt2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542374, updated on 18-Sep-2024

Summary

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Official Symbol
cdt2
Official Full Name
WD repeat protein Cdt2
Primary source
PomBase:SPAC17H9.19c
Locus tag
SPOM_SPAC17H9.19C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
sev1
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Genomic context

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See cdt2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2033768..2035704, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TOM complex subunit Tom22 Neighboring gene uncharacterized protein Neighboring gene Mdm10/Mdm12/Mmm1 complex subunit Mdm10 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitotic cohesin complex non-SMC subunit Psc3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1. Ralph E, et al. EMBO Rep, 2006 Nov. PMID 17039252, Free PMC Article
  2. Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen. Salguero I, et al. Curr Biol, 2012 Apr 24. PMID 22464192, Free PMC Article
  3. The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. Braun S, et al. Cell, 2011 Jan 7. PMID 21215368, Free PMC Article
  4. Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast. Moss J, et al. Genes Dev, 2010 Dec 1. PMID 21123655, Free PMC Article
  5. CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation. Zhang JM, et al. PLoS Genet, 2020 Jul. PMID 32692737, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdt2 level fluctuations are not sufficient to regulate Spd1 proteolysis and that the key step in this event is the interaction of Spd1 with the polymerase processivity factor proliferating cell nuclear antigen
    Title: Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen.
  2. Epe1 is the sole target of the Cul4-Ddb1(Cdt)2 complex whose destruction is necessary for the preservation of heterochromatin.
    Title: The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin.
  3. Data demonstrate that Cdt2, an unstable WD40 protein, is a regulatory subunit of Pcu4-Ddb1-CSN ubiquitin ligase
    Title: Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase.
  4. We show that Cdt2 and Ddb1 are needed for cell-cycle changes in Cdt1 levels in the absence of DNA damage.
    Title: DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WD repeat protein Cdt2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2033768..2035704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019020.3 → NP_593588.1  WD repeat protein Cdt2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593588.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10990
    Conserved Domains (3) summary
    COG2319
    Location:171 → 490
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:131 → 178
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:173 → 464
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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