U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ctse cathepsin E [ Rattus norvegicus (Norway rat) ]

Gene ID: 25424, updated on 10-Jul-2024

Summary

Go to the top of the page Help
Official Symbol
Ctseprovided by RGD
Official Full Name
cathepsin Eprovided by RGD
Primary source
RGD:2446
See related
EnsemblRapid:ENSRNOG00000006963 AllianceGenome:RGD:2446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CEA; CEB; Ctsea
Summary
Enables aspartic-type endopeptidase activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II and protein autoprocessing. Located in endosome. Orthologous to human CTSE (cathepsin E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 389.2), Thymus (RPKM 338.8) and 2 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ctse in Genome Data Viewer
Location:
13q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45644168..45666722)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43091954..43114509)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48426833..48449493)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 14 Neighboring gene arginine vasopressin receptor 1B Neighboring gene Rab7b, member RAS oncogene family Neighboring gene uncharacterized LOC134481493

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells. Tsukuba T, et al. FEBS J, 2006 Jan. PMID 16367762
  2. Mutational analysis of residues in two consensus motifs in the active sites of cathepsin E. Liu J, et al. J Biochem, 2002 Sep. PMID 12204120
  3. Identification of cellular compartments involved in processing of cathepsin E in primary cultures of rat microglia. Sastradipura DF, et al. J Neurochem, 1998 May. PMID 9572291
  4. Age-related and dexamethasone-induced changes in cathepsins E and D in rat thymic and splenic cells. Nishishita K, et al. Arch Biochem Biophys, 1996 Sep 15. PMID 8809073
  5. Transient forebrain ischemia induces increased expression and specific localization of cathepsins E and D in rat hippocampus and neostriatum. Nakanishi H, et al. Exp Neurol, 1993 Jun. PMID 8339772

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These observations suggest that the overexpression of CatE interferes with neuronal differentiation of P19 cells through an impairment of cell aggregate formation, possibly through proteolytic degradation of N-cadherin.
    Title: Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin.
  2. The mRNA and protein expression levels of MMP-12 and Cathepsin E were significantly up-regulated in lung tissues of rats with silicotic pulmonary fibrosis.
    Title: [Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats].
  3. These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.
    Title: Disruption of structural and functional integrity of alpha 2-macroglobulin by cathepsin E.
  4. examination of the significance of residues in the motifs of rat cathepsin E by substitution of Asp98, Asp283, and Thr284 with other residues using site-directed mutagenesis
    Title: Mutational analysis of residues in two consensus motifs in the active sites of cathepsin E.
  5. These data indicate that the catalytic activity, propeptides, and N-glycosylation of this protein are all essential for its processing, maturation, and trafficking.
    Title: Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoprocessing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cathepsin E
NP_001388196.1
NP_037070.2
XP_006249811.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401267.1 → NP_001388196.1  cathepsin E isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P16228, Q63701
    UniProtKB/TrEMBL
    A6IC25
    Related
    ENSRNOP00000048353.3, ENSRNOT00000048391.6

  2. NM_001429468.1 → NP_001416397.1  cathepsin E isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P16228, Q63701
    UniProtKB/TrEMBL
    A6IC25

  3. NM_012938.2 → NP_037070.2  cathepsin E isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6IC26
    Related
    ENSRNOP00000009242.2, ENSRNOT00000009241.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    45644168..45666722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249749.4 → XP_006249811.1  cathepsin E isoform X1

    Related
    ENSRNOP00000099258.1, ENSRNOT00000124948.1
    Conserved Domains (3) summary
    pfam00026
    Location:79 → 396
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:23 → 51
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:80 → 395
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16228.3 GenPept UniProtKB/Swiss-Prot:P16228

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous