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sst4 ESCRT 0 complex subunit sst4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542403, updated on 22-Jun-2024

Summary

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Gene symbol
sst4
Gene description
ESCRT 0 complex subunit sst4
Locus tag
SPOM_SPAC19A8.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
vps27
Old locus tag
SPAC19A8.05c
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Genomic context

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See sst4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2477871..2480031)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Imp4 Neighboring gene putative dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-22 sterol desaturase Erg5 Neighboring gene ncRNA Neighboring gene myotubularin family phosphatidylinositol-3-phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation. Onishi M, et al. Eukaryot Cell, 2007 Dec. PMID 17951524, Free PMC Article
  2. Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1. Wang YY, et al. EMBO J, 2021 Aug 2. PMID 34169534, Free PMC Article
  3. Ent3 and GGA adaptors facilitate diverse anterograde and retrograde trafficking events to and from the prevacuolar endosome. Yanguas F, et al. Sci Rep, 2019 Jul 24. PMID 31341193, Free PMC Article
  4. Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe. Onishi M, et al. Biosci Biotechnol Biochem, 2003 Aug. PMID 12951513
  5. ESCRTs Cooperate with a Selective Autophagy Receptor to Mediate Vacuolar Targeting of Soluble Cargos. Liu XM, et al. Mol Cell, 2015 Sep 17. PMID 26365378

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sst4p is a downstream factor of PtdIns 3-kinase and functions in forespore membrane formation
    Title: Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein ligase activity ISM
Inferred from Sequence Model
more info
  
Process Evidence Code Pubs
involved_in ascospore-type prospore assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytoplasm to vacuole targeting by the NVT pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in late endosome to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ESCRT-0 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT-0 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ESCRT 0 complex subunit sst4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2477871..2480031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019216.3 → NP_593787.1  ESCRT 0 complex subunit sst4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593787.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13821
    Conserved Domains (3) summary
    cd15735
    Location:168 → 226
    FYVE_spVPS27p_like; FYVE domain found in Schizosaccharomyces pombe vacuolar protein sorting-associated protein 27 (spVps27p) and similar proteins
    pfam02809
    Location:260 → 276
    UIM; Ubiquitin interaction motif
    cl02544
    Location:7 → 153
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials