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med20 mediator complex subunit Med20 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542421, updated on 18-Sep-2024

Summary

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Official Symbol
med20
Official Full Name
mediator complex subunit Med20
Primary source
PomBase:SPAC17G8.05
Locus tag
SPOM_SPAC17G8.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See med20 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (2350193..2351244)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ARP2/3 actin-organizing complex subunit Arc5 Neighboring gene ncRNA Neighboring gene dihydroxy-acid dehydratase Neighboring gene ncRNA Neighboring gene NuA4 and Swr1 complex YEATS family subunit Yaf9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of the Mediator subunit Med20 affects transcription of tRNA and other non-coding RNA genes in fission yeast. Carlsten JO, et al. Biochim Biophys Acta, 2016 Feb. PMID 26608234
  2. Structure of the Mediator head module. Larivière L, et al. Nature, 2012 Dec 20. PMID 23123849
  3. Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways. Linder T, et al. Nucleic Acids Res, 2008 May. PMID 18310102, Free PMC Article
  4. Core Mediator structure at 3.4 Å extends model of transcription initiation complex. Nozawa K, et al. Nature, 2017 May 11. PMID 28467824
  5. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. loss of Med20 leads to an accumulation of aberrant, readthrough tRNA transcripts. These transcripts are polyadenylated and targeted for degradation by the exosome.
    Title: Loss of the Mediator subunit Med20 affects transcription of tRNA and other non-coding RNA genes in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription initiation by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
mediator complex subunit Med20

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2350193..2351244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019159.3 → NP_593728.2  mediator complex subunit Med20 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593728.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10317
    Conserved Domains (1) summary
    pfam08612
    Location:1 → 180
    Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex
Nucleotide Protein
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