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gcn5 SAGA complex histone acetyltransferase catalytic subunit Gcn5 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542513, updated on 18-Sep-2024

Summary

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Official Symbol
gcn5
Official Full Name
SAGA complex histone acetyltransferase catalytic subunit Gcn5
Primary source
PomBase:SPAC1952.05
Locus tag
SPOM_SPAC1952.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
kat2
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Genomic context

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See gcn5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4973624..4975698)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene OUT family ubiquitin-specific cysteine protease Otu2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene ncRNA Neighboring gene checkpoint clamp complex protein Rad1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gcn5 facilitates Pol II progression, rather than recruitment to nucleosome-depleted stress promoters, in Schizosaccharomyces pombe. Sansó M, et al. Nucleic Acids Res, 2011 Aug. PMID 21515633, Free PMC Article
  2. Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. Yamada T, et al. EMBO J, 2004 Apr 21. PMID 14988732, Free PMC Article
  3. Interplay between chromatin modulators and histone acetylation regulates the formation of accessible chromatin in the upstream regulatory region of fission yeast fbp1. Adachi A, et al. Genes Genet Syst, 2018 May 3. PMID 28674280
  4. Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation. Nugent RL, et al. BMC Genomics, 2010 Jan 22. PMID 20096118, Free PMC Article
  5. HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress. Johnsson A, et al. EMBO Rep, 2009 Sep. PMID 19633696, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gcn5-mediated acetylation at MBF-regulated promoters induces the G1-S transcriptional wave.
    Title: Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.
  2. Our work reveals that SAGA is a direct target of nutrient-sensing pathways and has uncovered a mechanism by which TORC1 and TORC2 converge to control gene expression and cell fate decisions.
    Title: TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
  3. Data indicate that Spt-Ada-Gcn5 acetyltransferase (SAGA) coactivator complex contains a separable subcomplex known as the histone acetyltransferase (HAT) module that contains the HAT, Gcn5, bound to Sgf29.
    Title: Nucleosome competition reveals processive acetylation by the SAGA HAT module.
  4. Data indicate that the increase in leucine uptake in the gcn5Delta mutant was dependent on an amino acid permease gene, SPCC965.11c(+).
    Title: The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast.
  5. Gcn5 mediates eviction of nucleosomes positioned downstream of promoters, allowing efficient Pol II progression along the genes.
    Title: Gcn5 facilitates Pol II progression, rather than recruitment to nucleosome-depleted stress promoters, in Schizosaccharomyces pombe.
  6. Gcn5 is predominantly localized to coding regions of highly transcribed genes, where it collaborates antagonistically with the class-II histone deacetylase, Clr3, to modulate H3K14ac levels and transcriptional elongation.
    Title: HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress.
  7. Data show that SAGA plays distinct roles in the control of the switch from proliferation to differentiation in S. pombe through the dynamic and opposing activities of Gcn5 and Spt8.
    Title: The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
  8. The histone acetyltransferase Gcn5 is required for most histone H3 acetylation around the meiotic recombination hotspot M26. Deletion of gcn5 causes a significant delay in chromatin remodeling but only partial reduction of M26 meiotic recomb. freq. [gcn5]
    Title: Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K14 acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K18 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables peptide crotonyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of induction of conjugation with cellular fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of induction of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in pericentric heterochromatin EXP
Inferred from Experiment
more info
 PubMed 

General protein information

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Preferred Names
SAGA complex histone acetyltransferase catalytic subunit Gcn5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4973624..4975698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020236.3 → NP_594807.1  SAGA complex histone acetyltransferase catalytic subunit Gcn5 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594807.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9UUK2
    Conserved Domains (3) summary
    cd05509
    Location:347 → 446
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:95 → 454
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:170 → 245
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein
Heading Accession and Version

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