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rad1 checkpoint clamp complex protein Rad1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542558, updated on 18-Sep-2024

Summary

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Official Symbol
rad1
Official Full Name
checkpoint clamp complex protein Rad1
Primary source
PomBase:SPAC1952.07
Locus tag
SPOM_SPAC1952.07
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rad19
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Genomic context

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See rad1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (4978578..4980303)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene SAGA complex histone acetyltransferase catalytic subunit Gcn5 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene acetyl-CoA hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Checkpoint controls in Schizosaccharomyces pombe: rad1. Rowley R, et al. EMBO J, 1992 Apr. PMID 1563349, Free PMC Article
  2. A role for Myh1 in DNA repair after treatment with strand-breaking and crosslinking chemotherapeutic agents. Jansson K, et al. Environ Mol Mutagen, 2013 Jun. PMID 23677513
  3. The tumor suppressor homolog in fission yeast, myh1(+), displays a strong interaction with the checkpoint gene rad1(+). Jansson K, et al. Mutat Res, 2008 Sep 26. PMID 18675827
  4. A structural hinge in eukaryotic MutY homologues mediates catalytic activity and Rad9-Rad1-Hus1 checkpoint complex interactions. Luncsford PJ, et al. J Mol Biol, 2010 Oct 29. PMID 20816984, Free PMC Article
  5. Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay. Alao JP, et al. Mol Cancer Ther, 2009 Sep. PMID 19723888

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. myh1 rad1 double mutants exhibit morphological defects in the absence of DNA damaging agents.
    Title: The tumor suppressor homolog in fission yeast, myh1(+), displays a strong interaction with the checkpoint gene rad1(+).
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic G2/MI DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of checkpoint clamp complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
checkpoint clamp complex protein Rad1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4978578..4980303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020238.3 → NP_594809.1  checkpoint clamp complex protein Rad1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594809.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P22193
    Conserved Domains (2) summary
    pfam02144
    Location:2 → 262
    Rad1; Repair protein Rad1/Rec1/Rad17
    cl24017
    Location:8 → 281
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
Nucleotide Protein
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