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pre5 proteasome core particle subunit alpha 6 Pre5 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542559, updated on 18-Sep-2024

Summary

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Official Symbol
pre5
Official Full Name
proteasome core particle subunit alpha 6 Pre5
Primary source
PomBase:SPAC6G10.04c
Locus tag
SPOM_SPAC6G10.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pre5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (3220849..3222154, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene cell end marker Tea3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cardiolipin-specific phospholipase Cld1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TRAPP complex subunit Trs120

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Lasker K, et al. Proc Natl Acad Sci U S A, 2012 Jan 31. PMID 22307589, Free PMC Article
  2. Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Bohn S, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21098295, Free PMC Article
  3. The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast. Seo HD, et al. J Biol Chem, 2017 Oct 13. PMID 28784663, Free PMC Article
  4. Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes. Leitner A, et al. Proc Natl Acad Sci U S A, 2014 Jul 1. PMID 24938783, Free PMC Article
  5. Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast. Takeda K, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20133687, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome core particle subunit alpha 6 Pre5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3220849..3222154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019525.3 → NP_594101.1  proteasome core particle subunit alpha 6 Pre5 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594101.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14250
    Conserved Domains (2) summary
    COG0638
    Location:4 → 239
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03749
    Location:6 → 216
    proteasome_alpha_type_1; proteasome_alpha_type_1. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
Nucleotide Protein
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