U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sst2 AMSH-like ubiquitin-specific protease [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542606, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
sst2
Official Full Name
AMSH-like ubiquitin-specific protease
Primary source
PomBase:SPAC19B12.10
Locus tag
SPOM_SPAC19B12.10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See sst2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (4901611..4904311)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Atg8 deconjugator Atg4 Neighboring gene signal recognition particle subunit Srp14 Neighboring gene ncRNA Neighboring gene zinc finger ribosome biogenesis protein Neighboring gene ncRNA Neighboring gene SMN complex subunit Yip11/Gem2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystal structure of the Thr316Ala mutant of a yeast JAMM deubiquitinase: implication of active-site loop dynamics in catalysis. Shrestha R, et al. Acta Crystallogr F Struct Biol Commun, 2021 Jun 1. PMID 34100774, Free PMC Article
  2. Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase. Bueno AN, et al. Biochemistry, 2015 Oct 6. PMID 26368668, Free PMC Article
  3. Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product. Shrestha RK, et al. Biochemistry, 2014 May 20. PMID 24787148, Free PMC Article
  4. A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival. Beckley JR, et al. Mol Cell Proteomics, 2015 Dec. PMID 26412298, Free PMC Article
  5. Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe. Onishi M, et al. Biosci Biotechnol Biochem, 2003 Aug. PMID 12951513

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase.
    Title: Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase.
  2. AMSH associates with endosomes, inhibition would be relieved because of ubiquitin binding domains present on its endosomal binding partners that would shift the balance toward better recognition of polyubiquitin chains via the avidity effect.
    Title: Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
NOT enables K48-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables K63-linked deubiquitinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables K63-linked deubiquitinase activity HDA PubMed 
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal-dependent deubiquitinase activity HMP PubMed 
enables metal-dependent deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasm to vacuole targeting by the NVT pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in late endosome to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in late endosome to vacuole transport via multivesicular body sorting pathway EXP
Inferred from Experiment
more info
 PubMed 
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
AMSH-like ubiquitin-specific protease
NP_001342969.1
  • human AMSH/STAMBP protein homolog, ubiquitin specific-protease

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4901611..4904311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356187.2 → NP_001342969.1  AMSH-like ubiquitin-specific protease [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9P371
    Conserved Domains (2) summary
    cd08066
    Location:260 → 433
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:26 → 111
    USP8_dimer; USP8 dimerisation domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials