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gef1 RhoGEF for Cdc42 (Gef1) [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542635, updated on 18-Sep-2024

Summary

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Official Symbol
gef1
Official Full Name
RhoGEF for Cdc42 (Gef1)
Primary source
PomBase:SPAC24H6.09
Locus tag
SPOM_SPAC24H6.09
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See gef1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (469981..472990, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene sulfate transporter Neighboring gene phospho-2-dehydro-3-deoxyheptonate aldolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Cdc42 GEF, Gef1, through endocytosis organizes F-BAR Cdc15 along the actomyosin ring and promotes concentric furrowing. Onwubiko UN, et al. J Cell Sci, 2019 Feb 28. PMID 30709916, Free PMC Article
  2. F-BAR Cdc15 Promotes Cdc42 Activation During Cytokinesis and Cell Polarization in Schizosaccharomyces pombe. Hercyk BS, et al. Genetics, 2019 Dec. PMID 31591131, Free PMC Article
  3. Gef1p and Scd1p, the Two GDP-GTP exchange factors for Cdc42p, form a ring structure that shrinks during cytokinesis in Schizosaccharomyces pombe. Hirota K, et al. Mol Biol Cell, 2003 Sep. PMID 12972551, Free PMC Article
  4. Hob3p, the fission yeast ortholog of human BIN3, localizes Cdc42p to the division site and regulates cytokinesis. Coll PM, et al. EMBO J, 2007 Apr 4. PMID 17363901, Free PMC Article
  5. Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis. Wei B, et al. Mol Biol Cell, 2016 Apr 15. PMID 26941334, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Microtubules and the Tea1-Tea4-Pom1 axis counteract inappropriate Gef1 activity by regulating the localization of the Cdc42 GTPase-activating protein Rga4.
    Title: Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1-Tea4-Pom1 axis.
  2. Unique role of GEF1 in the regulation of distinct events during cytokinesis: Gef1 localizes first to the cytokinetic ring and promotes timely constriction.
    Title: Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of bipolar cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of bipolar cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic actomyosin contractile ring contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actomyosin contractile ring contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of division septum assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of division septum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment of cell polarity EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell cortex of growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site HDA PubMed 
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endocytic patch IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in medial cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RhoGEF for Cdc42 (Gef1)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    469981..472990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018344.3 → NP_592943.1  RhoGEF for Cdc42 (Gef1) [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592943.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09763
    Conserved Domains (1) summary
    cd00160
    Location:312 → 505
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
Nucleotide Protein
Heading Accession and Version

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