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dhp1 5'-3' exoribonuclease Dhp1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542674, updated on 18-Sep-2024

Summary

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Official Symbol
dhp1
Official Full Name
5'-3' exoribonuclease Dhp1
Primary source
PomBase:SPAC26A3.12c
Locus tag
SPOM_SPAC26A3.12C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rat1
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Genomic context

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See dhp1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (3356144..3361003, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene centaurin ADOP ribosylation factor GTPase-activating protein Neighboring gene mitochondrial omega-amidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene retrotransposable element/transposon Tf2-type Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast. Yague-Sanz C, et al. Nucleic Acids Res, 2021 Sep 7. PMID 34352089, Free PMC Article
  2. The dhp1(+) gene, encoding a putative nuclear 5'-->3' exoribonuclease, is required for proper chromosome segregation in fission yeast. Shobuike T, et al. Nucleic Acids Res, 2001 Mar 15. PMID 11238999, Free PMC Article
  3. Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Xiang S, et al. Nature, 2009 Apr 9. PMID 19194460, Free PMC Article
  4. Pac1 endonuclease and Dhp1p 5'-->3' exonuclease are required for U3 snoRNA termination in Schizosaccharomyces pombe. Nabavi S, et al. FEBS Lett, 2010 Aug 4. PMID 20609363
  5. lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast. Shah S, et al. Genes Dev, 2014 Feb 1. PMID 24493644, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences.
    Title: Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences.
  2. A function of Pdc2-Lsm1, in concert with Dhp1, regulating RNA by promoting its decapping/destruction in the nucleus of Schizosaccharomyces pombe was suggested.
    Title: Involvement of fission yeast Pdc2 in RNA degradation and P-body function.
  3. Dhp1 interacts with the Clr4/Suv39h methyltransferase complex and acts directly to nucleate heterochromatin. Our work uncovers a previously unidentified role for 3'-end processing and transcription termination machinery in gene silencing.
    Title: Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.
  4. Pac1 and Dhp1p are essential for RNA production and transcript termination.
    Title: Pac1 endonuclease and Dhp1p 5'-->3' exonuclease are required for U3 snoRNA termination in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 5'-3' RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' RNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IC
Inferred by Curator
more info
  
involved_in nuclear mRNA surveillance ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rapid tRNA decay EXP
Inferred from Experiment
more info
 PubMed 
involved_in tRNA surveillance IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Las1 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
5'-3' exoribonuclease Dhp1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3356144..3361003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019579.3 → NP_594155.1  5'-3' exoribonuclease Dhp1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594155.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P40848
    Conserved Domains (2) summary
    COG5049
    Location:1 → 981
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam03159
    Location:1 → 255
    XRN_N; XRN 5'-3' exonuclease N-terminus
Nucleotide Protein
Heading Accession and Version

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