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pot1 shelterin complex subunit Pot1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542703, updated on 18-Sep-2024

Summary

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Official Symbol
pot1
Official Full Name
shelterin complex subunit Pot1
Primary source
PomBase:SPAC26H5.06
Locus tag
SPOM_SPAC26H5.06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pot1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (4129224..4132350)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein Gid5 Neighboring gene ncRNA Neighboring gene IPT/TIG ankyrin repeat-containing transcription regulator Neighboring gene ncRNA Neighboring gene seven transmembrane receptor protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exploring Genetic Interactions with Telomere Protection Gene pot1 in Fission Yeast. Ueno M. Biomolecules, 2023 Feb 15. PMID 36830739, Free PMC Article
  2. Discrimination against RNA Backbones by a ssDNA Binding Protein. Lloyd NR, et al. Structure, 2018 May 1. PMID 29681468, Free PMC Article
  3. The telomeric protein Pot1 from Schizosaccharomyces pombe binds ssDNA in two modes with differing 3' end availability. Dickey TH, et al. Nucleic Acids Res, 2014 Sep. PMID 25074378, Free PMC Article
  4. Nonspecific recognition is achieved in Pot1pC through the use of multiple binding modes. Dickey TH, et al. Structure, 2013 Jan 8. PMID 23201273, Free PMC Article
  5. A small molecule inhibitor of Pot1 binding to telomeric DNA. Altschuler SE, et al. Biochemistry, 2012 Oct 9. PMID 22978652, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pot1 promotes telomere DNA replication via the Stn1-Ten1 complex in fission yeast.
    Title: Pot1 promotes telomere DNA replication via the Stn1-Ten1 complex in fission yeast.
  2. Exploring Genetic Interactions with Telomere Protection Gene pot1 in Fission Yeast.
    Title: Exploring Genetic Interactions with Telomere Protection Gene pot1 in Fission Yeast.
  3. The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
    Title: The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
  4. Study shows that The C-terminal domain of the DNA-binding domain, Pot1pC, exhibits non-specific ssDNA recognition and discriminates against RNA by utilizing non-compensatory binding modes that feature significant rearrangement of the binding interface.
    Title: Discrimination against RNA Backbones by a ssDNA Binding Protein.
  5. Thus, our results suggest that pik1(+) is required for the maintenance of circular chromosomes.
    Title: Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1.
  6. The conservation between fission yeast Tpz1-Pot1 and human TPP1-POT1 interactions resulted in mapping a human melanoma-associated POT1 mutation (A532P) to the TPP1-POT1 interface.
    Title: Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.
  7. Long G2 phase of pot1-rqh1 double mutant may allow time for the accumulation of recombination intermediates which disturb chromosome segregation and make cells sensitive to thiabendazole.
    Title: Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.
  8. The Pot1 DNA-binding domain is capable of binding DNA in at least two structurally distinct binding modes.
    Title: The telomeric protein Pot1 from Schizosaccharomyces pombe binds ssDNA in two modes with differing 3' end availability.
  9. Pot1 promiscuity is implemented through binding modes that thermodynamically compensate for base-substitutions through alternate stacking interactions and hydrogen-bonding networks.
    Title: Nonspecific recognition is achieved in Pot1pC through the use of multiple binding modes.
  10. Results indicate an unanticipated ssDNA-binding mode in which two SpPot1 molecules bind an oligonucleotide containing two telomeric repeats.
    Title: DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables G-rich strand telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded telomeric DNA binding EXP
Inferred from Experiment
more info
 PubMed 
enables single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere capping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
part_of nuclear telomere cap complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
part_of shelterin complex IC
Inferred by Curator
more info
 PubMed 
part_of telomere cap complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
shelterin complex subunit Pot1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4129224..4132350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019882.3 → NP_594453.1  shelterin complex subunit Pot1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594453.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13988
    Conserved Domains (2) summary
    smart00976
    Location:27 → 171
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    pfam16686
    Location:203 → 336
    POT1PC; ssDNA-binding domain of telomere protection protein
Nucleotide Protein
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