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spg1 GTPase Spg1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542761, updated on 18-Sep-2024

Summary

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Official Symbol
spg1
Official Full Name
GTPase Spg1
Primary source
PomBase:SPAC1565.06c
Locus tag
SPOM_SPAC1565.06C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
sid3
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Genomic context

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See spg1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (1299707..1301090, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene MAPK cascade adaptor protein Ste4 Neighboring gene protein Utp8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cullin-associated NEDD8-dissociated protein 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN. Wachowicz P, et al. J Cell Sci, 2015 Feb 15. PMID 25501816
  2. Identification of functional domains within the septation initiation network kinase, Cdc7. Mehta S, et al. J Biol Chem, 2006 Apr 14. PMID 16469735
  3. Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast. Furge KA, et al. Curr Biol, 1998 Aug 27. PMID 9742395
  4. Asymmetric segregation on spindle poles of the Schizosaccharomyces pombe septum-inducing protein kinase Cdc7p. Sohrmann M, et al. Genes Dev, 1998 Jan 1. PMID 9420333, Free PMC Article
  5. Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1. García-Cortés JC, et al. J Cell Biol, 2009 Sep 7. PMID 19736319, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data presented in this study suggest there are at least two, genetically separable, states of the septation initiation network; an early state that is dependent upon Plo1p for its establishment, and a late state, which is dependent upon Spg1p.
    Title: Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN.
  2. We propose a mechanism that limits the amount of the Byr4p-Cdc16p GAP to the amount required to inhibit Spg1p signalling.
    Title: Homoeostasis between the GTPase Spg1p and its GAP in the regulation of cytokinesis in S. pombe.
  3. a region adjacent to the kinase domain is responsible for Spg1 association and identified an overlapping but distinct SPB localization domain; Cdc7 associates with itself and exists as a dimer in vivo
    Title: Identification of functional domains within the septation initiation network kinase, Cdc7.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of mitotic division septum assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic division septum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septation initiation signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitotic spindle pole body EXP
Inferred from Experiment
more info
 PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
is_active_in mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTPase Spg1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1299707..1301090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018715.3 → NP_593285.1  GTPase Spg1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593285.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14312, P87027
    Conserved Domains (2) summary
    cd04128
    Location:11 → 192
    Spg1; Septum-promoting GTPase (Spg1)
    pfam00071
    Location:12 → 177
    Ras; Ras family
Nucleotide Protein
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