U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ura3 mitochondrial dihydroorotate dehydrogenase Ura3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542781, updated on 22-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
ura3
Gene description
mitochondrial dihydroorotate dehydrogenase Ura3
Locus tag
SPOM_SPAC57A10.12C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Old locus tag
SPAC57A10.12c
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ura3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (1385357..1387145, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene La-motif domain-containing protein Neighboring gene disulfide relay system thiol oxidase subunit Mia40 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent DNA replication ligase Cdc17

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Two different dihydroorotate dehydrogenases from yeast Saccharomyces kluyveri. Zameitat E, et al. FEBS Lett, 2004 Jun 18. PMID 15196933
  2. Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts. Nagy M, et al. Proc Natl Acad Sci U S A, 1992 Oct 1. PMID 1409592, Free PMC Article
  3. Polypeptone induces dramatic cell lysis in ura4 deletion mutants of fission yeast. Matsuo Y, et al. PLoS One, 2013. PMID 23555823, Free PMC Article
  4. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article
  5. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables dihydroorotate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydroorotate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine ribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mitochondrial dihydroorotate dehydrogenase Ura3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1385357..1387145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018748.3 → NP_593317.1  mitochondrial dihydroorotate dehydrogenase Ura3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593317.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P32747
    Conserved Domains (2) summary
    PLN02826
    Location:42 → 431
    PLN02826; dihydroorotate dehydrogenase
    cd04738
    Location:69 → 426
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous