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iec1 Ino80 complex subunit Iec1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542854, updated on 18-Sep-2024

Summary

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Official Symbol
iec1
Official Full Name
Ino80 complex subunit Iec1
Primary source
PomBase:SPAC144.02
Locus tag
SPOM_SPAC144.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See iec1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4653049..4654387)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Schizosaccharomyces specific protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene adenylosuccinate synthetase Ade2 Neighboring gene ncRNA Neighboring gene ornithine decarboxylase Spe1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3. Choi ES, et al. Nat Commun, 2017 Sep 13. PMID 28904333, Free PMC Article
  2. Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast. Tay Z, et al. PLoS One, 2013. PMID 23365689, Free PMC Article
  3. Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism. Hogan CJ, et al. Mol Cell Biol, 2010 Feb. PMID 19933844, Free PMC Article
  4. The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin. Shan CM, et al. Cell Rep, 2020 Dec 29. PMID 33378674, Free PMC Article
  5. Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast. Nguyen TT, et al. Sci Rep, 2015 Feb 11. PMID 25669599, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This suggests that the Iec1-Ino80 complex promotes transcription through nucleosome eviction.
    Title: Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding ISM
Inferred from Sequence Model
more info
  
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair-dependent chromatin remodeling EXP
Inferred from Experiment
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ino80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ino80 complex subunit Iec1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4653049..4654387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020092.3 → NP_594663.1  Ino80 complex subunit Iec1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594663.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9UTM0
    Conserved Domains (3) summary
    COG5048
    Location:1 → 249
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:108 → 129
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:92 → 119
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
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