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cul4 CLRC complex subunit, cullin 4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543116, updated on 18-Sep-2024

Summary

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Official Symbol
cul4
Official Full Name
CLRC complex subunit, cullin 4
Primary source
PomBase:SPAC3A11.08
Locus tag
SPOM_SPAC3A11.08
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
Cul-4; pcu4
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Genomic context

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See cul4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (3452945..3455747)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene dipeptidyl peptidase Neighboring gene plasma membrane sodium ion/proton antiporter Sod22 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NADH dehydrogenase Neighboring gene ncRNA Neighboring gene sorting nexin Mvp1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast. White SA, et al. PLoS One, 2014. PMID 25090107, Free PMC Article
  2. Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin. Jia S, et al. Nat Cell Biol, 2005 Oct. PMID 16127433
  3. Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms. Liu C, et al. Genes Dev, 2003 May 1. PMID 12695334, Free PMC Article
  4. TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation. Wei Y, et al. Nat Cell Biol, 2021 Mar. PMID 33574613, Free PMC Article
  5. The Clr7 and Clr8 directionality factors and the Pcu4 cullin mediate heterochromatin formation in the fission yeast Schizosaccharomyces pombe. Thon G, et al. Genetics, 2005 Dec. PMID 16157682, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of biochemical interactions demonstrates that the RFTS domain mediates an interaction between Raf2 and the CLRC component Cul4
    Title: The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast.
  2. Components of the Clr4 histone K3-K9 methyltransferase-Rik1-Cullin4 complex act concertedly at an early step in heterochromatin formation.
    Title: A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.
  3. Data demonstrate that Cdt2, an unstable WD40 protein, is a regulatory subunit of Pcu4-Ddb1-CSN ubiquitin ligase
    Title: Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pericentric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in siRNA-mediated pericentric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in silent mating-type cassette heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription-coupled nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CLRC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex EXP
Inferred from Experiment
more info
 PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in mating-type region heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in subtelomeric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CLRC complex subunit, cullin 4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3452945..3455747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019619.3 → NP_594195.1  CLRC complex subunit, cullin 4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594195.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14122, Q9USB6
    Conserved Domains (3) summary
    smart00182
    Location:416 → 554
    CULLIN; Cullin
    smart00884
    Location:663 → 730
    Cullin_Nedd8; Cullin protein neddylation domain
    COG5647
    Location:1 → 734
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version

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