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rad2 FEN-1 endonuclease Rad2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543164, updated on 18-Sep-2024

Summary

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Official Symbol
rad2
Official Full Name
FEN-1 endonuclease Rad2
Primary source
PomBase:SPAC3G6.06c
Locus tag
SPOM_SPAC3G6.06C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
fen1
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Genomic context

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See rad2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (5389586..5391422, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Mpv17/PMP22 family protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene sulfhydryl oxidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Schizosaccharomyces pombe Rad2 protein, a FEN-1 homolog. Alleva JL, et al. Nucleic Acids Res, 1998 Aug 15. PMID 9685478, Free PMC Article
  2. Activation of an alternative, rec12 (spo11)-independent pathway of fission yeast meiotic recombination in the absence of a DNA flap endonuclease. Farah JA, et al. Genetics, 2005 Dec. PMID 16118186, Free PMC Article
  3. Binding and repair of mismatched DNA mediated by Rhp14, the fission yeast homologue of human XPA. Hohl M, et al. J Biol Chem, 2001 Aug 17. PMID 11408483
  4. A recombination repair gene of Schizosaccharomyces pombe, rhp57, is a functional homolog of the Saccharomyces cerevisiae RAD57 gene and is phylogenetically related to the human XRCC3 gene. Tsutsui Y, et al. Genetics, 2000 Apr. PMID 10747044, Free PMC Article
  5. The nature of the 5'-terminus is a major determinant for DNA processing by Schizosaccharomyces pombe Rad2p, a FEN-1 family nuclease. Alleva JL, et al. Nucleic Acids Res, 2000 Aug 1. PMID 10908351, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fen-1 and Swi-7 proteins act together in the S-phase alkylation damage response in S. pombe.
    Title: DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.
  2. Ast1 promotes checkpoint activation caused by the absence of the other XPG-related nucleases, Exo1 and Rad2, the homologue of Fen1.
    Title: Initiation of DNA damage responses through XPG-related nucleases.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 5'-3' DNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-3' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-flap endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA 5'-3' DNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA 5'-3' DNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication, removal of RNA primer IEA
Inferred from Electronic Annotation
more info
  
involved_in UV-damage excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UV-damage excision repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in base-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial DNA metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
FEN-1 endonuclease Rad2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5389586..5391422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020403.3 → NP_594972.1  FEN-1 endonuclease Rad2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594972.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P39750
    Conserved Domains (3) summary
    cd09907
    Location:222 → 291
    H3TH_FEN1-Euk; H3TH domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease: Eukaryotic homologs
    cd09867
    Location:4 → 345
    PIN_FEN1; PIN domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    PTZ00217
    Location:1 → 379
    PTZ00217; flap endonuclease-1; Provisional
Nucleotide Protein
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Gene LinkOut

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