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abc2 vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Abc2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543193, updated on 18-Sep-2024

Summary

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Official Symbol
abc2
Official Full Name
vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Abc2
Primary source
PomBase:SPAC3F10.11c
Locus tag
SPOM_SPAC3F10.11C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See abc2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2837121..2841788, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription factor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Thr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. Mendoza-Cózatl DG, et al. J Biol Chem, 2010 Dec 24. PMID 20937798, Free PMC Article
  2. A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant. Iwaki T, et al. Microbiology (Reading), 2006 Aug. PMID 16849797
  3. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
  4. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article
  5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ABC-type phytochelatin transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular detoxification of cadmium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutathione transmembrane import into vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phytochelatin 2 import into vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus HDA PubMed 
is_active_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Abc2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2837121..2841788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019371.4 → NP_593943.3  vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Abc2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593943.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P78928, Q10185
    Conserved Domains (4) summary
    TIGR00957
    Location:96 → 1477
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1237 → 1456
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:593 → 798
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:928 → 1190
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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