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rad4 BRCT domain protein Rad4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543281, updated on 18-Sep-2024

Summary

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Official Symbol
rad4
Official Full Name
BRCT domain protein Rad4
Primary source
PomBase:SPAC23C4.18c
Locus tag
SPOM_SPAC23C4.18C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
cut5; dpb11; dre3
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Genomic context

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See rad4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (1058646..1062912, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase subunit Rpb5 Neighboring gene ncRNA Neighboring gene autophagy-associated lipase Atg15 Neighboring gene tRNA (cytosine-5-)-methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DSIF transcription elongation factor complex subunit Spt5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast. Verkade HM, et al. Mol Gen Genet, 1998 Dec. PMID 9894912
  2. Schizosaccharomyces pombe Rad4/Cut5 protein modification and chromatin binding changes in DNA damage. Siam R, et al. DNA Cell Biol, 2007 Aug. PMID 17688408
  3. Rad4TopBP1 associates with Srr2, an Spc1 MAPK-regulated protein, in response to environmental stress. Taricani L, et al. J Biol Chem, 2007 Mar 23. PMID 17272281
  4. Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: dissection of DNA replication and G2 checkpoint control function. McFarlane RJ, et al. Mol Gen Genet, 1997 Jul. PMID 9268024
  5. Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+. Saka Y, et al. Cell, 1993 Jul 30. PMID 8343962

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show multiple BRCT domains within TOPBP1/Rad4 achieve selective and combinatorial binding of their multiple partner proteins.
    Title: BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.
  2. Rad4 mainly functions as a scaffold protein in the Chk1, not the Cds1(CHK2 in humans), checkpoint pathway. It plays a minor role or is functionally redundant with an unknown factor in Rad3 activation.
    Title: Rad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombe.
  3. we show that the simultaneous interaction of a single Rad4(TopBP1) molecule with both Thr187 phosphorylation sites in a Crb2(53BP1) dimer is essential for establishing the DNA damage checkpoint.
    Title: Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1).
  4. data indicate that Rad4 undergoes diverse forms of regulation that are distinct in both DNA replication and checkpoint response
    Title: Schizosaccharomyces pombe Rad4/Cut5 protein modification and chromatin binding changes in DNA damage.
  5. These data suggest that Rad4TopBP1 provides a scaffold to a large complex containing checkpoint and replication proteins thereby separately enforcing checkpoint responses to DNA damage and replication perturbations during the cell cycle.
    Title: Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling adaptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA damage checkpoint signaling EXP
Inferred from Experiment
more info
 PubMed 
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle HDA PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
NOT is_active_in nuclear replication fork IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BRCT domain protein Rad4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1058646..1062912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018586.3 → NP_593190.1  BRCT domain protein Rad4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593190.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P32372
    Conserved Domains (3) summary
    smart00292
    Location:4 → 75
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:395 → 473
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12738
    Location:105 → 167
    PTCB-BRCT; twin BRCT domain
Nucleotide Protein
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