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cpc2 40S ribosomal protein RACK1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543298, updated on 18-Sep-2024

Summary

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Official Symbol
cpc2
Official Full Name
40S ribosomal protein RACK1
Primary source
PomBase:SPAC6B12.15
Locus tag
SPOM_SPAC6B12.15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rkp1
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Genomic context

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See cpc2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (2439511..2441027)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene protein meu26

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast. Núñez A, et al. Mol Biol Cell, 2009 Sep. PMID 19625445, Free PMC Article
  2. Cpc2, a fission yeast homologue of mammalian RACK1 protein, interacts with Ran1 (Pat1) kinase To regulate cell cycle progression and meiotic development. McLeod M, et al. Mol Cell Biol, 2000 Jun. PMID 10805744, Free PMC Article
  3. Rkp1/Cpc2, a fission yeast RACK1 homolog, is involved in actin cytoskeleton organization through protein kinase C, Pck2, signaling. Won M, et al. Biochem Biophys Res Commun, 2001 Mar 23. PMID 11263963
  4. Cpc2/RACK1 is a ribosome-associated protein that promotes efficient translation in Schizosaccharomyces pombe. Shor B, et al. J Biol Chem, 2003 Dec 5. PMID 12972434
  5. Role of the RNA-binding protein Nrd1 in stress granule formation and its implication in the stress response in fission yeast. Satoh R, et al. PLoS One, 2012. PMID 22276125, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cmk2 kinase is essential for survival in arsenite by modulating translation together with RACK1 orthologue Cpc2 in Schizosaccharomyces pombe.
    Title: Cmk2 kinase is essential for survival in arsenite by modulating translation together with RACK1 orthologue Cpc2 in Schizosaccharomyces pombe.
  2. S. pombe Cpc2 facilitates the GAAC response through the regulation of Gcn2 activation
    Title: Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.
  3. in fission yeast Cpc2/RACK1 positively regulates from the ribosome the mitotic onset by modulating both the protein levels and the activity of Wee1
    Title: Fission yeast receptor of activated C kinase (RACK1) ortholog Cpc2 regulates mitotic commitment through Wee1 kinase.
  4. Cpc2 negatively regulates the cell integrity transduction pathway and positively regulates the synthesis of the stress-responsive transcription factor Atf1 and the cytoplasmic catalase.
    Title: Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.
  5. A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.
    Title: A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal small subunit binding EXP
Inferred from Experiment
more info
 PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor activator activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation activator activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in GCN2-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell integrity MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translational frameshifting IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane EXP
Inferred from Experiment
more info
 PubMed 

General protein information

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Preferred Names
40S ribosomal protein RACK1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2439511..2441027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019200.3 → NP_593770.1  40S ribosomal protein RACK1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593770.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P78896, Q10281
    Conserved Domains (3) summary
    COG2319
    Location:7 → 310
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:7 → 311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:18 → 61
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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