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spp42 U5 snRNP complex subunit Spp42 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543413, updated on 18-Sep-2024

Summary

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Official Symbol
spp42
Official Full Name
U5 snRNP complex subunit Spp42
Primary source
PomBase:SPAC4F8.12c
Locus tag
SPOM_SPAC4F8.12C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
cwf6
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Genomic context

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See spp42 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2650719..2658024)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene IQ motif containing GTPase activating protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SEACAT complex subunit Sea2 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. All-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome. Casalino L, et al. Proc Natl Acad Sci U S A, 2018 Jun 26. PMID 29891649, Free PMC Article
  2. spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p. Schmidt H, et al. Genetics, 1999 Nov. PMID 10545451, Free PMC Article
  3. Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe. Bottner CA, et al. Curr Genet, 2005 Sep. PMID 16133344
  4. Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing. McDonald WH, et al. Mol Cell Biol, 1999 Aug. PMID 10409726, Free PMC Article
  5. Genome-wide mapping of myosin protein-RNA networks suggests the existence of specialized protein production sites. Mata J. FASEB J, 2010 Feb. PMID 19805578

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables U1 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U5 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISM
Inferred from Sequence Model
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA intronic binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA cis splicing, via spliceosome EXP
Inferred from Experiment
more info
 PubMed 
involved_in spliceosomal conformational changes to generate catalytic conformation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spliceosomal tri-snRNP complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Prp19 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of post-mRNA release spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
U5 snRNP complex subunit Spp42

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2650719..2658024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019290.3 → NP_593861.1  U5 snRNP complex subunit Spp42 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593861.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14187
    Conserved Domains (1) summary
    COG5178
    Location:33 → 2363
    PRP8; U5 snRNP spliceosome subunit [RNA processing and modification]
Nucleotide Protein
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