U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

orb6 serine/threonine protein kinase Orb6 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543441, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
orb6
Official Full Name
serine/threonine protein kinase Orb6
Primary source
PomBase:SPAC821.12
Locus tag
SPOM_SPAC821.12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See orb6 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (1008263..1010318)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene gamma-glutamyl phosphate reductase Pro1 Neighboring gene P-type ATPase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Conserved Orb6 phosphorylation sites are essential for polarized cell growth in Schizosaccharomyces pombe. Liu G, et al. PLoS One, 2012. PMID 22629372, Free PMC Article
  2. Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle. Verde F, et al. Proc Natl Acad Sci U S A, 1998 Jun 23. PMID 9636183, Free PMC Article
  3. Pak1 kinase controls cell shape through ribonucleoprotein granules. Magliozzi JO, et al. Elife, 2021 Jul 20. PMID 34282727, Free PMC Article
  4. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Tay YD, et al. Cell Rep, 2019 Feb 5. PMID 30726745, Free PMC Article
  5. Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p. Das M, et al. Mol Biol Cell, 2007 Jun. PMID 17377067, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pak1 kinase controls cell shape through ribonucleoprotein granules.
    Title: Pak1 kinase controls cell shape through ribonucleoprotein granules.
  2. Orb6 phosphorylation of Sec3 contributes to exocyst function in concert with exocyst protein Exo70.
    Title: Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
  3. The authors find that Orb6 kinase inhibits Sts5 recruitment into ribonucleoprotein granules, its association with processing (P) bodies, and degradation of Sts5-bound mRNAs by promoting Sts5 interaction with 14-3-3 protein Rad24.
    Title: Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5.
  4. Lrp1 proved to function upstream of Orb6 in cell morphogenesis
    Title: Fission yeast leucine-rich repeat protein Lrp1 is essential for cell morphogenesis as a component of the morphogenesis Orb6 network (MOR).
  5. our results suggest a model whereby autophosphorylation of Ser291 and phosphorylation of Thr456 by an upstream kinase promote Nak1/Orb6 complex formation and Orb6 activation.
    Title: Conserved Orb6 phosphorylation sites are essential for polarized cell growth in Schizosaccharomyces pombe.
  6. The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42.
    Title: The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RAM/MOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to salt stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of protein location in cell cortex of cell tip IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of fungal-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine protein kinase Orb6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1008263..1010318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018563.3 → NP_593165.1  serine/threonine protein kinase Orb6 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593165.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13310
    Conserved Domains (2) summary
    smart00220
    Location:93 → 392
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05629
    Location:91 → 461
    STKc_NDR_like_fungal; Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials