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scm3 CENP-A histone chaperone Scm3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543449, updated on 18-Sep-2024

Summary

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Official Symbol
scm3
Official Full Name
CENP-A histone chaperone Scm3
Primary source
PomBase:SPAPB1A10.02
Locus tag
SPOM_SPAPB1A10.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
sim1
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Genomic context

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See scm3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (1861807..1863132)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ornithine cyclodeaminase family protein Neighboring gene cell surface adhesion protein for conjugation Mam3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mRNA export receptor Nxt1 Neighboring gene protein dpc13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Epigenetically induced paucity of histone H2A.Z stabilizes fission-yeast ectopic centromeres. Ogiyama Y, et al. Nat Struct Mol Biol, 2013 Dec. PMID 24186062
  2. Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin. Pidoux AL, et al. Mol Cell, 2009 Feb 13. PMID 19217404, Free PMC Article
  3. Mis16 Independently Recognizes Histone H4 and the CENP-ACnp1-Specific Chaperone Scm3sp. An S, et al. J Mol Biol, 2015 Oct 9. PMID 26343758
  4. Inner Kinetochore Protein Interactions with Regional Centromeres of Fission Yeast. Thakur J, et al. Genetics, 2015 Oct. PMID 26275423, Free PMC Article
  5. Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin. Williams JS, et al. Mol Cell, 2009 Feb 13. PMID 19217403, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cysteine-rich domain in CENP-A chaperone Scm3HJURP ensures centromere targeting and kinetochore integrity.
    Title: The cysteine-rich domain in CENP-A chaperone Scm3HJURP ensures centromere targeting and kinetochore integrity.
  2. Scm3(Sp) coaffinity purifies with CENP-A(Cnp1) and associates with CENP-A(Cnp1) in vitro, yet localizes independently of intact CENP-A(Cnp1) chromatin and is differentially released from chromatin.
    Title: Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.
  3. the dynamic behavior of S. pombe Scm3 suggests that it acts as a Cnp1 assembly/maintenance factor that directly mediates the stable deposition of Cnp1 into centromeric chromatin.
    Title: Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone chaperone activity NAS
Non-traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome, centromeric core domain IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
CENP-A histone chaperone Scm3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1861807..1863132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018950.3 → NP_593516.1  CENP-A histone chaperone Scm3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593516.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9HDY7
    Conserved Domains (1) summary
    pfam10384
    Location:38 → 90
    Scm3; Centromere protein Scm3
Nucleotide Protein
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