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mst1 histone acetyltransferase, KAT5 family Mst1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543506, updated on 14-Nov-2024

Summary

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Official Symbol
mst1
Official Full Name
histone acetyltransferase, KAT5 family Mst1
Primary source
PomBase:SPAC637.12c
Locus tag
SPOM_SPAC637.12C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
kat5
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Genomic context

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See mst1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4559101..4562829, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative ribonuclease H70 Neighboring gene ncRNA Neighboring gene 19S proteasome regulatory subunit Rpn10 Neighboring gene ATP-dependent RNA helicase Rpm2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cytoskeletal signaling protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromodomain mutation in S. pombe Kat5/Mst1 affects centromere dynamics and DNA repair. Li T, et al. PLoS One, 2024. PMID 38662722, Free PMC Article
  2. Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double-strand break. Li T, et al. Genetics, 2021 May 17. PMID 33723569, Free PMC Article
  3. The fission yeast inhibitor of growth (ING) protein Png1p functions in response to DNA damage. Chen JQ, et al. J Biol Chem, 2010 May 21. PMID 20299455, Free PMC Article
  4. BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere. Minoda A, et al. Mol Biol Cell, 2005 Jan. PMID 15483052, Free PMC Article
  5. The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning. Noguchi C, et al. Epigenetics Chromatin, 2019 Apr 16. PMID 30992049, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chromodomain mutation in S. pombe Kat5/Mst1 affects centromere dynamics and DNA repair.
    Title: Chromodomain mutation in S. pombe Kat5/Mst1 affects centromere dynamics and DNA repair.
  2. Mst1 plays essential roles in maintenance of genome stability and recovery from DNA damage.
    Title: Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K4 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone crotonyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide 2-hydroxyisobutyryltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide N-acetyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables peptide butyryltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Swr1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone acetyltransferase, KAT5 family Mst1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4559101..4562829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020058.3 → NP_594630.1  histone acetyltransferase, KAT5 family Mst1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594630.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94446, Q9USC8
    Conserved Domains (3) summary
    COG5027
    Location:16 → 447
    SAS2; Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]
    pfam11717
    Location:21 → 74
    Tudor-knot; RNA binding activity-knot of a chromodomain
    cl17182
    Location:176 → 451
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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