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cdc3 profilin [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543526, updated on 18-Sep-2024

Summary

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Official Symbol
cdc3
Official Full Name
profilin
Primary source
PomBase:SPAC4A8.15c
Locus tag
SPOM_SPAC4A8.15C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See cdc3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (2578956..2579525, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribose-phosphate pyrophosphokinase Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene translation initiation factor eIF3c Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Profilin binding to poly-L-proline and actin monomers along with ability to catalyze actin nucleotide exchange is required for viability of fission yeast. Lu J, et al. Mol Biol Cell, 2001 Apr. PMID 11294914, Free PMC Article
  2. Regulation and targeting of the fission yeast formin cdc12p in cytokinesis. Yonetani A, et al. Mol Biol Cell, 2008 May. PMID 18305104, Free PMC Article
  3. F-actin distribution and function during sexual differentiation in Schizosaccharomyces pombe. Petersen J, et al. J Cell Sci, 1998 Apr. PMID 9490631
  4. The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis. Balasubramanian MK, et al. J Cell Biol, 1994 Jun. PMID 8207058, Free PMC Article
  5. Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12. Bestul AJ, et al. Mol Biol Cell, 2015 Jan 15. PMID 25392301, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the essential role of profilin is to specifically facilitate formin Cdc12-mediated actin assembly for cytokinesis.
    Title: Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cortical patch organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytogamy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cortical patch TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell cortex of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in medial cortex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
profilin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2578956..2579525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019256.3 → NP_593827.1  profilin [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593827.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P39825
    Conserved Domains (1) summary
    pfam00235
    Location:1 → 124
    Profilin
Nucleotide Protein
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