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myp2 Myo3-like myosin II heavy chain myp2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543576, updated on 6-Oct-2024

Summary

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Official Symbol
myp2
Official Full Name
Myo3-like myosin II heavy chain myp2
Primary source
PomBase:SPAC4A8.05c
Locus tag
SPOM_SPAC4A8.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
myo3
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Genomic context

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See myp2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2547260..2553703, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene vacuolar serine protease Isp6 Neighboring gene ncRNA Neighboring gene esterase/lipase Neighboring gene ncRNA Neighboring gene sphinganine kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Counting actin in contractile rings reveals novel contributions of cofilin and type II myosins to fission yeast cytokinesis. Malla M, et al. Mol Biol Cell, 2022 May 15. PMID 34613787, Free PMC Article
  2. Motor Activity Dependent and Independent Functions of Myosin II Contribute to Actomyosin Ring Assembly and Contraction in Schizosaccharomyces pombe. Palani S, et al. Curr Biol, 2017 Mar 6. PMID 28238661, Free PMC Article
  3. Contractile ring stability in S. pombe depends on F-BAR protein Cdc15p and Bgs1p transport from the Golgi complex. Arasada R, et al. Cell Rep, 2014 Sep 11. PMID 25159149, Free PMC Article
  4. Genetic interaction between calcineurin and type 2 myosin and their involvement in the regulation of cytokinesis and chloride ion homeostasis in fission yeast. Fujita M, et al. Genetics, 2002 Jul. PMID 12136004, Free PMC Article
  5. Myosin-II tails confer unique functions in Schizosaccharomyces pombe: characterization of a novel myosin-II tail. Bezanilla M, et al. Mol Biol Cell, 2000 Jan. PMID 10637292, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We provide evidence that the myosin II protein Myp2 and the myosin V protein Myo51 play roles in recruiting TORC2 to the CAR.We go on to show that TORC2-dependent phosphorylation of actin-capping protein 1 (Acp1, a known regulator of cytokinesis) controls CAR stability, modulates Acp1-Acp2 heterodimer formation and is essential for survival upon stress.
    Title: TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.
  2. Three myosins function in a hierarchal, complementary manner to accomplish cytokinesis, with Myo2 and Myo51 taking the lead during contractile ring assembly and Myp2 making the greatest contribution to constriction.
    Title: Three myosins contribute uniquely to the assembly and constriction of the fission yeast cytokinetic contractile ring.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic actomyosin contractile ring assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic actomyosin contractile ring contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic actomyosin contractile ring contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration during mitotic telophase IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin ring complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in medial cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring, proximal layer IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Myo3-like myosin II heavy chain myp2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2547260..2553703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019246.3 → NP_593816.1  Myo3-like myosin II heavy chain myp2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593816.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14157, O42730, Q9UU49
    Conserved Domains (5) summary
    COG5022
    Location:17 → 1607
    COG5022; Myosin heavy chain [General function prediction only]
    cd01377
    Location:103 → 755
    MYSc_class_II; class II myosins, motor domain
    pfam02736
    Location:38 → 76
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam08581
    Location:1684 → 1759
    Tup_N; Tup N-terminal
    cl23720
    Location:1997 → 2072
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
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