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ZDHHC24 zinc finger DHHC-type containing 24 [ Homo sapiens (human) ]

Gene ID: 254359, updated on 5-Mar-2024

Summary

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Official Symbol
ZDHHC24provided by HGNC
Official Full Name
zinc finger DHHC-type containing 24provided by HGNC
Primary source
HGNC:HGNC:27387
See related
Ensembl:ENSG00000174165 AllianceGenome:HGNC:27387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 1.8), kidney (RPKM 1.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66520625..66546048, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66516865..66542290, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66288096..66313519, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66243741-66244561 Neighboring gene pellino E3 ubiquitin protein ligase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66245199-66245792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66246731-66247298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5045 Neighboring gene DPP3 divergent transcript Neighboring gene skeletal muscle cis-regulatory module in DPP3 intron Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66258390-66259340 Neighboring gene dipeptidyl peptidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5046 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66298267-66298846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66298847-66299424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66307071-66307841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5049 Neighboring gene Sharpr-MPRA regulatory region 1034 Neighboring gene actinin alpha 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66332233-66332732 Neighboring gene cathepsin F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Nat Genet, 2011 Sep 18. PMID 21926972, Free PMC Article
  2. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  4. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable palmitoyltransferase ZDHHC24
Names
DHHC-24
zinc finger DHHC domain-containing protein 24
zinc finger, DHHC domain containing 24
NP_001335500.1
NP_997223.1
XP_005273931.1
XP_011543195.1
XP_011543196.1
XP_047282665.1
XP_047282666.1
XP_054224277.1
XP_054224278.1
XP_054224279.1
XP_054224280.1
XP_054224281.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348571.2 → NP_001335500.1  probable palmitoyltransferase ZDHHC24 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK310561, AP002748
    Consensus CDS
    CCDS86218.1
    UniProtKB/TrEMBL
    E9PLR9
    Related
    ENSP00000431321.1, ENST00000526986.5
    Conserved Domains (1) summary
    cl19890
    Location:95 → 169
    zf-DHHC; DHHC palmitoyltransferase

  2. NM_207340.3 → NP_997223.1  probable palmitoyltransferase ZDHHC24 isoform 1

    See identical proteins and their annotated locations for NP_997223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP002748, AY358448
    Consensus CDS
    CCDS8143.1
    UniProtKB/Swiss-Prot
    Q6PEW7, Q6UX98, Q9BSJ0
    UniProtKB/TrEMBL
    B4DX31
    Related
    ENSP00000309429.3, ENST00000310442.5
    Conserved Domains (1) summary
    pfam01529
    Location:95 → 234
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    66520625..66546048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273874.5 → XP_005273931.1  probable palmitoyltransferase ZDHHC24 isoform X3

    See identical proteins and their annotated locations for XP_005273931.1

    UniProtKB/TrEMBL
    E9PI61
    Related
    ENSP00000436503.1, ENST00000534073.5
    Conserved Domains (1) summary
    cl19890
    Location:95 → 169
    zf-DHHC; DHHC palmitoyltransferase

  2. XM_047426710.1 → XP_047282666.1  probable palmitoyltransferase ZDHHC24 isoform X4

  3. XM_011544894.3 → XP_011543196.1  probable palmitoyltransferase ZDHHC24 isoform X3

    See identical proteins and their annotated locations for XP_011543196.1

    UniProtKB/TrEMBL
    E9PI61
    Conserved Domains (1) summary
    cl19890
    Location:95 → 169
    zf-DHHC; DHHC palmitoyltransferase

  4. XM_047426709.1 → XP_047282665.1  probable palmitoyltransferase ZDHHC24 isoform X1

  5. XM_011544893.4 → XP_011543195.1  probable palmitoyltransferase ZDHHC24 isoform X2

    Conserved Domains (1) summary
    cl19890
    Location:95 → 169
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. XR_007062470.1 RNA Sequence

  2. XR_949860.4 RNA Sequence

  3. XR_007062471.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    66516865..66542290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368304.1 → XP_054224279.1  probable palmitoyltransferase ZDHHC24 isoform X3

    UniProtKB/TrEMBL
    E9PI61

  2. XM_054368306.1 → XP_054224281.1  probable palmitoyltransferase ZDHHC24 isoform X4

  3. XM_054368305.1 → XP_054224280.1  probable palmitoyltransferase ZDHHC24 isoform X3

    UniProtKB/TrEMBL
    E9PI61

  4. XM_054368302.1 → XP_054224277.1  probable palmitoyltransferase ZDHHC24 isoform X1

  5. XM_054368303.1 → XP_054224278.1  probable palmitoyltransferase ZDHHC24 isoform X2

RNA

  1. XR_008488376.1 RNA Sequence

  2. XR_008488378.1 RNA Sequence

  3. XR_008488377.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UX98.1 GenPept UniProtKB/Swiss-Prot:Q6UX98

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