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rad31 SUMO activating enzyme E1-type Rad31 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543606, updated on 18-Sep-2024

Summary

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Official Symbol
rad31
Official Full Name
SUMO activating enzyme E1-type Rad31
Primary source
PomBase:SPAC4C5.04
Locus tag
SPOM_SPAC4C5.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
uba4
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Genomic context

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See rad31 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (1198391..1199733)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene multispanning membrane protein, CTNS/PQ domain protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Andrews EA, et al. Mol Cell Biol, 2005 Jan. PMID 15601841, Free PMC Article
  2. SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52. Ho JC, et al. Nucleic Acids Res, 2001 Oct 15. PMID 11600706, Free PMC Article
  3. Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance. Shayeghi M, et al. Nucleic Acids Res, 1997 Mar 15. PMID 9092625, Free PMC Article
  4. SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage. Wei Y, et al. Mol Cell, 2017 Jun 1. PMID 28552615
  5. Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation. Xu X, et al. Proc Natl Acad Sci U S A, 2019 May 28. PMID 31072933, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables SUMO activating enzyme activity EXP
Inferred from Experiment
more info
 PubMed 
enables SUMO activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO activating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic chromosome condensation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein sumoylation EXP
Inferred from Experiment
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SUMO activating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
SUMO activating enzyme E1-type Rad31

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1198391..1199733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018648.3 → NP_593251.1  SUMO activating enzyme E1-type Rad31 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593251.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P79064
    Conserved Domains (2) summary
    COG0476
    Location:4 → 184
    ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]
    cd01492
    Location:11 → 305
    Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
Nucleotide Protein
Heading Accession and Version

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