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fas2 fatty acid synthase alpha subunit Fas2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543618, updated on 18-Sep-2024

Summary

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Official Symbol
fas2
Official Full Name
fatty acid synthase alpha subunit Fas2
Primary source
PomBase:SPAC4A8.11c
Locus tag
SPOM_SPAC4A8.11C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
lsd1
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Genomic context

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See fas2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2566866..2572618, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein Cwf21 Neighboring gene lipase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine/threonine protein phosphatase PP1 regulatory subunit Sds22 Neighboring gene 20S proteasome complex subunit beta 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Very-long-chain fatty acid-containing phospholipids accumulate in fatty acid synthase temperature-sensitive mutant strains of the fission yeast Schizosaccharomyces pombe fas2/lsd1. Yokoyama K, et al. Biochim Biophys Acta, 2001 Jun 29. PMID 11470243
  2. Aberrant mitosis in fission yeast mutants defective in fatty acid synthetase and acetyl CoA carboxylase. Saitoh S, et al. J Cell Biol, 1996 Aug. PMID 8769419, Free PMC Article
  3. S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Lan F, et al. Mol Cell, 2007 Apr 13. PMID 17434129
  4. Cloning of the fatty acid synthetase beta subunit from fission yeast, coexpression with the alpha subunit, and purification of the intact multifunctional enzyme complex. Niwa H, et al. Protein Expr Purif, 1998 Aug. PMID 9693066
  5. A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast. Mathiassen SG, et al. J Biol Chem, 2015 Aug 21. PMID 26152728, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty acid synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to fatty-acyl-CoA synthase activity TAS
Traceable Author Statement
more info
 PubMed 
enables holo-[acyl-carrier-protein] synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic nuclear membrane biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in palmitic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
part_of fatty acid synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of fatty acid synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fatty acid synthase alpha subunit Fas2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2566866..2572618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019252.3 → NP_593823.1  fatty acid synthase alpha subunit Fas2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593823.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14163, P78866, P78973, Q10289, Q96WT6, Q96WT7, Q96WT8, Q9URI5
    Conserved Domains (6) summary
    cd08950
    Location:629 → 888
    KR_fFAS_SDR_c_like; ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs
    COG0331
    Location:21 → 86
    FabD; Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]
    COG4982
    Location:95 → 1126
    FabG2; 3-oxoacyl-ACP reductase domain of yeast-type FAS1 [Lipid transport and metabolism]
    cd00828
    Location:1094 → 1614
    elong_cond_enzymes; "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as ...
    PTZ00050
    Location:1137 → 1606
    PTZ00050; 3-oxoacyl-acyl carrier protein synthase; Provisional
    TIGR00556
    Location:1721 → 1842
    pantethn_trn; phosphopantetheine--protein transferase domain
Nucleotide Protein
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