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pol1 DNA polymerase alpha catalytic subunit [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543629, updated on 18-Sep-2024

Summary

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Official Symbol
pol1
Official Full Name
DNA polymerase alpha catalytic subunit
Primary source
PomBase:SPAC3H5.06c
Locus tag
SPOM_SPAC3H5.06C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
polA; swi7
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Genomic context

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See pol1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (3430955..3436241)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene WD repeat-containing protein Neighboring gene ncRNA Neighboring gene 60S ribosomal protein L7b Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS11 Neighboring gene U5 snRNP-associated protein Aar2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast. D'Urso G, et al. J Cell Sci, 1995 Sep. PMID 8537450
  2. DNA polymerase-alpha is essential for mating-type switching in fission yeast. Singh J, et al. Nature, 1993 Jan 21. PMID 8423854
  3. In vivo phosphorylation, mitotic behavior, and nuclear binding of the catalytic subunit of DNA polymerase alpha in fission yeast. Bouvier D, et al. Exp Cell Res, 1993 Jul. PMID 8319772
  4. Studies of Schizosaccharomyces pombe DNA polymerase alpha at different stages of the cell cycle. Park H, et al. Nucleic Acids Res, 1995 Nov 11. PMID 7501454, Free PMC Article
  5. Chromodomain protein Swi6-mediated role of DNA polymerase alpha in establishment of silencing in fission Yeast. Ahmed S, et al. J Biol Chem, 2001 Dec 21. PMID 11581276

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fen-1 and Swi-7 proteins act together in the S-phase alkylation damage response in S. pombe.
    Title: DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.
  2. GINS functions in a pathway that involves Cdc45 and is necessary for DNA polymerase epsilon chromatin binding, but a separate pathway sets up the chromatin association of DNA polymerase alpha.
    Title: GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gene conversion at mating-type locus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lagging strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear cell cycle DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in premeiotic DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase alpha catalytic subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3430955..3436241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019610.3 → NP_594186.1  DNA polymerase alpha catalytic subunit [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594186.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P28040, Q9UTY1
    Conserved Domains (5) summary
    cd05776
    Location:522 → 757
    DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
    cd05532
    Location:829 → 1218
    POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
    TIGR00592
    Location:40 → 1200
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:1238 → 1403
    zf-DNA_Pol; DNA Polymerase alpha zinc finger
    pfam12254
    Location:15 → 78
    DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal
Nucleotide Protein
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