btn1 battenin CLN3 family protein [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: btn1
Official Full Name: battenin CLN3 family protein
Primary source: PomBase:SPAC607.09c
Locus tag: SPOM_SPAC607.09C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: cln3
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Genomic context

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See btn1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (2050462..2051748, complement)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease.
Title: Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease.
mutations in CLN3 have a role in the fission yeast model for the lysosomal storage disorder Batten disease
Title: The fission yeast model for the lysosomal storage disorder Batten disease predicts disease severity caused by mutations in CLN3.
S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p.
Title: S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p.
Btn1p impacts two independent processes, which suggests that Batten disease is more than a pH-related lysosome disorder.
Title: Btn1 affects cytokinesis and cell-wall deposition by independent mechanisms, one of which is linked to dysregulation of vacuole pH.
btn1 affects endocytosis, polarization of sterol-rich membrane domains and polarized growth in Schizosaccharomyces pombe.
Title: btn1 affects endocytosis, polarization of sterol-rich membrane domains and polarized growth in Schizosaccharomyces pombe.
This gene, btn1, encodes a predicted transmembrane protein that is 30% identical and 48% similar to its human counterpart.
Title: btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables transmembrane transporter activity	ISM Inferred from Sequence Model more info

Process	Evidence Code	Pubs
involved_in L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell division site	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum membrane	IC Inferred by Curator more info
is_active_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vacuole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: battenin CLN3 family protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

2050462..2051748 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001019029.3 → NP_593598.1 battenin CLN3 family protein [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593598.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q9US09

Conserved Domains (1) summary

pfam02487
Location:16 → 383

CLN3; CLN3 protein