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Ggh gamma-glutamyl hydrolase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25455, updated on 2-Nov-2024

Summary

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Symbol
Gghprovided by RGD
Full Name
gamma-glutamyl hydrolaseprovided by RGD
Primary source
RGD:2682
See related
EnsemblRapid:ENSRNOG00000007351 AllianceGenome:RGD:2682
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables gamma-glutamyl-peptidase activity. Involved in several processes, including response to ethanol; response to insulin; and response to zinc ion. Located in extracellular space. Orthologous to human GGH (gamma-glutamyl hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 360.7), Spleen (RPKM 264.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ggh in Genome Data Viewer
Location:
5q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (38326747..38349655)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (33529880..33552790)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (34040258..34063369)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478943 Neighboring gene U4 spliceosomal RNA Neighboring gene alpha tocopherol transfer protein Neighboring gene Sodium/potassium transporting ATPase interacting 3 Neighboring gene histone deacetylase 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Quercetin induces hepatic γ-glutamyl hydrolase expression in rats by suppressing hepatic microRNA rno-miR-125b-3p. Wein SA, et al. J Nutr Biochem, 2015 Dec. PMID 26432773
  2. The effect of dietary zinc depletion and repletion on rats: Zn concentration in various tissues and activity of pancreatic gamma-glutamyl hydrolase (EC 3.4.22.12) as indices of Zn status. Canton MC, et al. Br J Nutr, 1990 Jul. PMID 2400760
  3. Subcellular fractionation of liver organelles from phenobarbital-treated rats by counter-current partition and sucrose gradient centrifugation. Morris WB, et al. Biochem Pharmacol, 1986 Jul 1. PMID 3015147
  4. Effect of chronic ethanol consumption on the cellular and subcellular distribution of gamma-glutamyltransferase in rat liver. Halsall S, et al. Enzyme, 1984. PMID 6147245
  5. Insulin-dependent suppression in glutamyl hydrolase activity and elevated cellular methotrexate polyglutamates. Galivan J, et al. Biochem Pharmacol, 1995 Nov 9. PMID 7503769

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hepatic microRNA rno-miR-125b-3p is suppressed by quercetin-induced hepatic gamma-glutamyl hydrolase expression in rats
    Title: Quercetin induces hepatic γ-glutamyl hydrolase expression in rats by suppressing hepatic microRNA rno-miR-125b-3p.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC105496

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gamma-glutamyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-glutamyl-peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables gamma-glutamyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables gamma-glutamyl-peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to insulin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to zinc ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tetrahydrofolylpolyglutamate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-glutamyl hydrolase
Names
GH
conjugase
gamma-Glu-X carboxypeptidase
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
NP_037092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012960.2 → NP_037092.1  gamma-glutamyl hydrolase precursor

    See identical proteins and their annotated locations for NP_037092.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087602
    UniProtKB/Swiss-Prot
    Q62867
    UniProtKB/TrEMBL
    A6IID6
    Related
    ENSRNOP00000009758.3, ENSRNOT00000009758.7
    Conserved Domains (2) summary
    pfam07722
    Location:34 → 245
    Peptidase_C26; Peptidase C26
    cl00020
    Location:36 → 305
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    38326747..38349655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62867.1 GenPept UniProtKB/Swiss-Prot:Q62867

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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