Hrh2 histamine receptor H 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hrh2provided by RGD
Official Full Name: histamine receptor H 2provided by RGD
Primary source: RGD:2831
See related: EnsemblRapid:ENSRNOG00000018260 AllianceGenome:RGD:2831
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H2R; HH2R
Summary: Enables heterocyclic compound binding activity and histamine receptor activity. Involved in cellular response to histamine and negative regulation of arachidonate secretion. Predicted to be located in synapse. Predicted to be active in dendrite and plasma membrane. Biomarker of transient cerebral ischemia. Orthologous to human HRH2 (histamine receptor H2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 17.7), Spleen (RPKM 8.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (10371083..10412979, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (10366004..10407791, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (10912959..10931389, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the histaminergic afferent inputs in the striatum may modulate both dopamine D1 and D2 receptor-expressing medium spiny projection neurons by activation of postsynaptic histamine H1 and H2 receptors.
Title: Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors.
findings indicate that histamine H1, H2, and H3 receptors are present in rat olfactory epithelium and may play a physiological role in olfactory transmission.
Title: Expression and localization of histamine H(1), H(2), and H(3) receptors in rat olfactory epithelium.
Isolated rat mesenteric collecting lymphatics were treated with 1- to 100-muM histamine. Pharmacologic blockade of either H1 or H2 histamine receptors significantly inhibited the response to histamine.
Title: Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Na+-Ca2+ exchangers coupled to H1 receptors and hyperpolarization-activated cyclic nucleotide-gated channels linked to H2 receptors co-mediate the strong postsynaptic excitatory action of histamine on al vestibular nucleus neurons
Title: Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats.
Histamine H2 receptors, unlike the H1 receptor type, do not mediate emotional memory consolidation impairment.
Title: Emotional memory consolidation impairment induced by histamine is mediated by H1 but not H2 receptors.
Data suggest histamine stimulates proliferation of Leydig tumor cells via activation of HRH2 and a transient increase in intracellular cAMP levels. Normal/immature Leydig cells and progenitor Leydig cells exhibit very low levels of HDC expression.
Title: Proliferative effect of histamine on MA-10 Leydig tumor cells mediated through HRH2 activation, transient elevation in cAMP production, and increased extracellular signal-regulated kinase phosphorylation levels.
Data suggest that histamine facilitates consolidation of fear extinction through mechanism involving Hrh2-dependent phosphorylation of ERK1 in hippocampus.
Title: Histamine facilitates consolidation of fear extinction.
at the level of the hippocampus, histamine through its H1 and H2 receptors, mediates orofacial region pain
Title: Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats.
Data show that famotidine, a H2 receptor antagonist, decreases the late phase of orthodontic tooth movement in rats.
Title: Famotidine, a H2 receptor antagonist, decreases the late phase of orthodontic tooth movement in rats.
Postischemic iecrease in H(2) receptor binding densities in the caudate-putamen.
Title: Postischemic regulation of central histamine receptors.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Hrh2 (e-PCR), detects polymorphism
- UniSTS:164925

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heterocyclic compound binding	IDA Inferred from Direct Assay more info	PubMed
enables histamine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables histamine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables histamine receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to histamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within digestive tract development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in gastric acid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrin-induced gastric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within histamine-induced gastric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of arachidonate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histamine H2 receptor

Names: gastric receptor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.