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Il1rap interleukin 1 receptor accessory protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 25466, updated on 25-Apr-2024

Summary

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Official Symbol
Il1rapprovided by RGD
Official Full Name
interleukin 1 receptor accessory proteinprovided by RGD
Primary source
RGD:2893
See related
Ensembl:ENSRNOG00000001928 AllianceGenome:RGD:2893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IL-1RAcp; Il1racpb
Summary
Enables interleukin-1 receptor binding activity. Predicted to be involved in several processes, including interleukin-33-mediated signaling pathway; positive regulation of cytokine production; and regulation of synapse assembly. Predicted to act upstream of or within cytokine-mediated signaling pathway and positive regulation of dendrite development. Located in cytoplasm. Part of protein-containing complex. Orthologous to human IL1RAP (interleukin 1 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 121.4), Brain (RPKM 69.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Il1rap in Genome Data Viewer
Location:
11q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (87567813..87704346, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (74062999..74199530, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (77456648..77593208, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene geminin coiled-coil domain containing Neighboring gene uncharacterized LOC134481020 Neighboring gene uncharacterized LOC120095686 Neighboring gene transmembrane protein 207 Neighboring gene claudin 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interleukin (IL)-1 in rat parturition: IL-1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term - regulation by progesterone. Ishiguro T, et al. Physiol Rep, 2016 Jul. PMID 27440742, Free PMC Article
  2. Up-regulation of IL-1 receptor through PI3K/Akt is essential for the induction of iNOS gene expression in hepatocytes. Teshima S, et al. J Hepatol, 2004 Apr. PMID 15030977
  3. Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies. Liu C, et al. J Neuroimmunol, 1996 May. PMID 8964912
  4. IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Ali S, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 18003919, Free PMC Article
  5. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. Chackerian AA, et al. J Immunol, 2007 Aug 15. PMID 17675517

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activity of Il-1 in parturition is regulated by progesterone via Il1R1/Il1R2/Il-1RAcp pathway.
    Title: Interleukin (IL)-1 in rat parturition: IL-1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term - regulation by progesterone.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC114349

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
  
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 binding TAS
Traceable Author Statement
more info
 PubMed 
enables interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables interleukin-1 receptor binding TAS
Traceable Author Statement
more info
 PubMed 
enables interleukin-33 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-33 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-33-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-33-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic density assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in trans-synaptic signaling by trans-synaptic complex IEA
Inferred from Electronic Annotation
more info
  
involved_in trans-synaptic signaling by trans-synaptic complex ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-1 receptor accessory protein
Names
IL-1 receptor accessory protein
NP_001161312.1
NP_037100.1
XP_063126379.1
XP_063126380.1
XP_063126381.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167840.2 → NP_001161312.1  interleukin-1 receptor accessory protein isoform b precursor

    See identical proteins and their annotated locations for NP_001161312.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    D1M8S3, F1LRE8
    Related
    ENSRNOP00000051260.4, ENSRNOT00000043498.7
    Conserved Domains (5) summary
    smart00255
    Location:404 → 547
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:145 → 150
    Ig; Ig strand A [structural motif]
    cd20931
    Location:243 → 349
    Ig3_IL1RAP; Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP)
    cd20992
    Location:25 → 132
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:143 → 235
    Ig; Immunoglobulin domain

  2. NM_012968.1 → NP_037100.1  interleukin-1 receptor accessory protein precursor

    See identical proteins and their annotated locations for NP_037100.1

    Status: PROVISIONAL

    Source sequence(s)
    U48592
    UniProtKB/Swiss-Prot
    Q63621
    UniProtKB/TrEMBL
    A6JRY5, F1M9B9
    Related
    ENSRNOP00000002645.3, ENSRNOT00000002645.5
    Conserved Domains (4) summary
    cd00096
    Location:262 → 346
    Ig; Immunoglobulin domain
    PHA02785
    Location:3 → 334
    PHA02785; IL-beta-binding protein; Provisional
    pfam01582
    Location:405 → 546
    TIR; TIR domain
    cl11960
    Location:26 → 131
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    87567813..87704346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270311.1 → XP_063126381.1  interleukin-1 receptor accessory protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6ACY6

  2. XM_063270309.1 → XP_063126379.1  interleukin-1 receptor accessory protein isoform X1

    UniProtKB/TrEMBL
    D1M8S3, F1LRE8

  3. XM_063270310.1 → XP_063126380.1  interleukin-1 receptor accessory protein isoform X1

    UniProtKB/TrEMBL
    D1M8S3, F1LRE8

RNA

  1. XR_010055935.1 RNA Sequence

  2. XR_010055934.1 RNA Sequence

  3. XR_010055936.1 RNA Sequence

  4. XR_010055933.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63621.1 GenPept UniProtKB/Swiss-Prot:Q63621

Gene LinkOut

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