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Lhcgr luteinizing hormone/choriogonadotropin receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25477, updated on 2-Nov-2024

Summary

Official Symbol
Lhcgrprovided by RGD
Official Full Name
luteinizing hormone/choriogonadotropin receptorprovided by RGD
Primary source
RGD:3007
See related
EnsemblRapid:ENSRNOG00000016712 AllianceGenome:RGD:3007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lhr; LSHR; LSH-R; LH/CG-R
Summary
Enables several functions, including ATPase binding activity; identical protein binding activity; and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; and positive regulation of calcium ion transmembrane transport. Located in endosome and extracellular space. Part of receptor complex. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 193.3) and Uterus (RPKM 13.9) See more
Orthologs
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Genomic context

See Lhcgr in Genome Data Viewer
Location:
6q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (11415361..11480834)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (5661871..5728109)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (12493182..12554482, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479269 Neighboring gene uncharacterized LOC134479270 Neighboring gene pyruvate kinase PKM-like Neighboring gene general transcription factor 2A subunit 1 like Neighboring gene uncharacterized LOC120103455 Neighboring gene stonin 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables choriogonadotropin hormone binding IEA
Inferred from Electronic Annotation
more info
 
enables choriogonadotropin hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables choriogonadotropin hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables choriogonadotropin hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables luteinizing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables luteinizing hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables luteinizing hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables luteinizing hormone receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables peptide hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide hormone binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in arachidonate secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to gonadotropin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to luteinizing hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to luteinizing hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to luteinizing hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cognition IEA
Inferred from Electronic Annotation
more info
 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in development of secondary male sexual characteristics IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within development of secondary male sexual characteristics ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within female gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in luteinizing hormone signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in luteinizing hormone signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in luteinizing hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in luteinizing hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in ovarian follicle development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in ovulation cycle process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ovulation cycle process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ovulation cycle process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of hormone biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inositol trisphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inositol trisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of steroid biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of steroid hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to luteinizing hormone IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in seminiferous tubule development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within seminiferous tubule development ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in uterus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within uterus development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lutropin-choriogonadotropic hormone receptor
Names
LH receptor
LH/CG receptor
luteinizing hormone receptor
luteinizing hormone/chorionic gonadotropin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433211.1NP_001420140.1  lutropin-choriogonadotropic hormone receptor precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
  2. NM_012978.3NP_037110.1  lutropin-choriogonadotropic hormone receptor precursor

    See identical proteins and their annotated locations for NP_037110.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P16235, P70646, Q63807, Q63808, Q63809, Q6LDI7
    UniProtKB/TrEMBL
    A6H9B2, F1LMG6
    Related
    ENSRNOP00000022481.6, ENSRNOT00000022481.9
    Conserved Domains (3) summary
    sd00033
    Location:5578
    LRR_RI; leucine-rich repeat [structural motif]
    cd15359
    Location:365638
    7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam13306
    Location:66204
    LRR_5; Leucine rich repeats (6 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    11415361..11480834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261562.1XP_063117632.1  lutropin-choriogonadotropic hormone receptor isoform X3

  2. XM_039111807.2XP_038967735.1  lutropin-choriogonadotropic hormone receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I6GK42, F1LMG6
    Conserved Domains (3) summary
    sd00033
    Location:5377
    LRR_RI; leucine-rich repeat [structural motif]
    cd15359
    Location:339612
    7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam13306
    Location:40178
    LRR_5; Leucine rich repeats (6 copies)
  3. XM_039111808.2XP_038967736.1  lutropin-choriogonadotropic hormone receptor isoform X2

    Conserved Domains (1) summary
    cd15359
    Location:149422
    7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors