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Mmp11 matrix metallopeptidase 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25481, updated on 2-Nov-2024

Summary

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Symbol
Mmp11provided by RGD
Full Name
matrix metallopeptidase 11provided by RGD
Primary source
RGD:3099
See related
EnsemblRapid:ENSRNOG00000028344 AllianceGenome:RGD:3099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ST3
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within basement membrane organization; collagen fibril organization; and negative regulation of fat cell differentiation. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human MMP11 (matrix metallopeptidase 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 339.0), Kidney (RPKM 64.7) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mmp11 in Genome Data Viewer
Location:
20p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12730284..12739067)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12730846..12739629)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13670051..13678834)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene similar to human chromosome 22 open reading frame 15 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene uncharacterized LOC134483889 Neighboring gene derlin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues. Okada A, et al. Gene, 1997 Feb 7. PMID 9055814
  2. Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions. Motrescu ER, et al. Oncogene, 2008 Oct 23. PMID 18622425
  3. Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. Ng DC, et al. J Cell Biol, 2006 Jan 16. PMID 16401721, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within basement membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within collagen catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stromelysin-3
Names
MMP-11
Matrix metalloproteinase 11 (stromelysin 3)
SL-3
matrix metalloproteinase-11
NP_037112.2
XP_038954388.1
XP_063135049.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012980.2 → NP_037112.2  stromelysin-3 precursor

    See identical proteins and their annotated locations for NP_037112.2

    Status: VALIDATED

    Source sequence(s)
    BC099781, BI291437, CK602095, U46034
    UniProtKB/Swiss-Prot
    P97568, Q499S5
    UniProtKB/TrEMBL
    A0A8L2R8J4, A6JKF2
    Related
    ENSRNOP00000035334.5, ENSRNOT00000031400.7
    Conserved Domains (2) summary
    cd00094
    Location:294 → 483
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:108 → 261
    Peptidase_M10; Matrixin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    12730284..12739067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098460.2 → XP_038954388.1  stromelysin-3 isoform X1

    Conserved Domains (2) summary
    cd00094
    Location:135 → 324
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:1 → 102
    Peptidase_M10; Matrixin

  2. XM_063278979.1 → XP_063135049.1  stromelysin-3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499S5.1 GenPept UniProtKB/Swiss-Prot:Q499S5

Gene LinkOut

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