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MORN5 MORN repeat containing 5 [ Homo sapiens (human) ]

Gene ID: 254956, updated on 2-Nov-2024

Summary

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Official Symbol
MORN5provided by HGNC
Official Full Name
MORN repeat containing 5provided by HGNC
Primary source
HGNC:HGNC:17841
See related
Ensembl:ENSG00000185681 MIM:619837; AllianceGenome:HGNC:17841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf18; C9orf113
Summary
Predicted to be located in sperm flagellum. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 7.1), heart (RPKM 2.0) and 21 other tissues See more
Orthologs
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Genomic context

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See MORN5 in Genome Data Viewer
Location:
9q33.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (122159908..122200083)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (134357378..134397571)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (124922187..124962362)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124887422-124888188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124888189-124888954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124888955-124889721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124889722-124890487 Neighboring gene microRNA 4478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124896063-124896602 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124896718-124897622 Neighboring gene NADH:ubiquinone oxidoreductase subunit A8 Neighboring gene Sharpr-MPRA regulatory region 3979 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:124962138-124962350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20240 Neighboring gene LIM homeobox 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124988963-124989468 Neighboring gene MPRA-validated peak7328 silencer Neighboring gene RNA binding motif protein 18 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:125026651-125027850

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. Letra A, et al. Am J Med Genet A, 2010 Jul. PMID 20583170, Free PMC Article
  2. Genome-wide association study of smoking behaviours among Bangladeshi adults. Argos M, et al. J Med Genet, 2014 May. PMID 24665060, Free PMC Article
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of smoking behaviours among Bangladeshi adults.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ46909, FLJ50034

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
MORN repeat-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286828.2 → NP_001273757.1  MORN repeat-containing protein 5 isoform b

    See identical proteins and their annotated locations for NP_001273757.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AI560944, AK128877, BC143440, HY011325
    Consensus CDS
    CCDS75894.1
    UniProtKB/TrEMBL
    A0A0A0MTF6
    Related
    ENSP00000437483.2, ENST00000536616.5
    Conserved Domains (1) summary
    cl27415
    Location:5 → 62
    COG4642; Uncharacterized conserved protein [Function unknown]

  2. NM_198469.4 → NP_940871.2  MORN repeat-containing protein 5 isoform a

    See identical proteins and their annotated locations for NP_940871.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI560944, AK128877, BC133690, HY011325
    Consensus CDS
    CCDS6836.1
    UniProtKB/Swiss-Prot
    B7Z7I5, Q5VZ52, Q6ZQN1
    Related
    ENSP00000362869.3, ENST00000373764.8
    Conserved Domains (1) summary
    cl27415
    Location:5 → 76
    COG4642; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    122159908..122200083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    134357378..134397571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VZ52.1 GenPept UniProtKB/Swiss-Prot:Q5VZ52

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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