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Rps5 ribosomal protein S5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25538, updated on 2-Nov-2024

Summary

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Official Symbol
Rps5provided by RGD
Official Full Name
ribosomal protein S5provided by RGD
Primary source
RGD:3601
See related
EnsemblRapid:ENSRNOG00000019453 AllianceGenome:RGD:3601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA binding activity and rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in regulation of translational fidelity; ribosomal small subunit assembly; and translation. Part of cytosolic small ribosomal subunit. Orthologous to human RPS5 (ribosomal protein S5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 3706.9), Thymus (RPKM 2969.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rps5 in Genome Data Viewer
Location:
1q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (82610965..82615262)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (73538776..73543073)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (65660470..65664767, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 22 Neighboring gene uncharacterized LOC134482891 Neighboring gene ring finger protein 225 Neighboring gene uncharacterized LOC134482890

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis. Xu WH, et al. Hepatology, 2014 Aug. PMID 24668691
  2. The primary structure of rat ribosomal protein S5. A ribosomal protein present in the rat genome in a single copy. Kuwano Y, et al. J Biol Chem, 1992 Dec 15. PMID 1460027
  3. Expression of ribosomal protein S5 cloned gene during differentiation and apoptosis in murine erythroleukemia (MEL) cells. Vizirianakis IS, et al. Oncol Res, 1999. PMID 10821535
  4. Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5. Galkin O, et al. RNA, 2007 Dec. PMID 17901157, Free PMC Article
  5. Electron microscopic investigations on the location of rat liver ribosomal proteins S3a, S5, S6, S7 and S9 by means of antibody labeling. Lutsch G, et al. Biomed Biochim Acta, 1983. PMID 6196023

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate that RPS5 is implicated in hepatic fibrogenesis.
    Title: Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of translational fidelity ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS7
Names
40S ribosomal protein S5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277243.1 → NP_001264172.1  small ribosomal subunit protein uS7 isoform 1

    See identical proteins and their annotated locations for NP_001264172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    FM052146, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P24050
    UniProtKB/TrEMBL
    B0BN81, F7FP79
    Related
    ENSRNOP00000026528.4, ENSRNOT00000026528.9
    Conserved Domains (1) summary
    cd14867
    Location:18 → 204
    uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7

  2. NM_001277244.1 → NP_001264173.1  small ribosomal subunit protein uS7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    FM052146, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P24050
    Related
    ENSRNOP00000072051.3, ENSRNOT00000088367.3
    Conserved Domains (1) summary
    cd14867
    Location:18 → 171
    uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    82610965..82615262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105722.1: Suppressed sequence

    Description
    NM_001105722.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24050.3 GenPept UniProtKB/Swiss-Prot:P24050

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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