Scp2 sterol carrier protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scp2provided by RGD
Official Full Name: sterol carrier protein 2provided by RGD
Primary source: RGD:3642
See related: Ensembl:ENSRNOG00000011413 AllianceGenome:RGD:3642
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SCPx; NSLIPTR
Summary: Enables C-acyltransferase activity; identical protein binding activity; and lipid transfer activity. Involved in several processes, including cellular response to cholesterol; monocarboxylic acid metabolic process; and positive regulation of cholesterol biosynthetic process. Located in several cellular components, including endoplasmic reticulum; mitochondrion; and peroxisomal matrix. Is extrinsic component of mitochondrial outer membrane. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 2343.5), Heart (RPKM 584.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (128035714..128110015, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (122806949..122881259, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (127647934..127735703, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that type II natural killer T cells reactive with autologous SCP2 are implicated in vascular inflammation in the rat model.
Title: Type II Natural Killer T Cells that Recognize Sterol Carrier Protein 2 Are Implicated in Vascular Inflammation in the Rat Model of Systemic Connective Tissue Diseases.
These data are in agreement with the findings that diabetes, a medical condition characterized by high levels of fatty acids in an insulin deficient environment, enhances the hepatic expression of SCPx.
Title: Lauric acid dependent enhancement in hepatic SCPx protein requires an insulin deficient environment.
MLN64 has roles with StAR, and SCP-2 in regulating bile acid synthesis
Title: Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis.
Expression of the SCPx gene is regulated by PPARalpha; mechanism of this regulation occurs mainly through binding and activation of two peroxisomal-proliferator-response element motifs found in the promoter of the SCPx gene.
Title: Peroxisome proliferator-activated receptor alpha induces rat sterol carrier protein x promoter activity through two peroxisome proliferator-response elements.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141299 (e-PCR)
- UniSTS:223295

D4Rat90 (e-PCR), detects polymorphism
- UniSTS:118881

RH140895 (e-PCR)
- UniSTS:222911

SCP2 (e-PCR)
- UniSTS:105162

RH128646 (e-PCR)
- UniSTS:211954

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetyl-CoA C-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA C-myristoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA C-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables fatty-acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables oleic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylethanolamine transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol transfer activity	ISO Inferred from Sequence Orthology more info
enables propanoyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cholesterol	IEP Inferred from Expression Pattern more info	PubMed
involved_in fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in inositol trisphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in intracellular cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid hydroperoxide transport	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cholesterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cholesterol import	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of steroid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of phospholipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to luteinizing hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sterol transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sterol carrier protein 2

Names: NSL-TP; SCP-2; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-X; SCP-chi; Sterol carrier protein 2, liver; acetyl-CoA C-myristoyltransferase; non-specific lipid-transfer protein; propanoyl-CoA C-acyltransferase; sterol carrier protein X; straight-chain acyl-CoA oxidase

NP_612517.3

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138508.5 → NP_612517.3 sterol carrier protein 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P11915, Q63383, Q642G0

UniProtKB/TrEMBL

A6JYU0

Related

ENSRNOP00000015420.6, ENSRNOT00000015420.6

Conserved Domains (2) summary

PRK08256
Location:12 → 404

PRK08256; lipid-transfer protein; Provisional

pfam02036
Location:452 → 538

SCP2; SCP-2 sterol transfer family