U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc34a1 solute carrier family 34 member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25548, updated on 2-Nov-2024

Summary

Official Symbol
Slc34a1provided by RGD
Official Full Name
solute carrier family 34 member 1provided by RGD
Primary source
RGD:3708
See related
EnsemblRapid:ENSRNOG00000015262 AllianceGenome:RGD:3708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Npt2; NaPi-2; NaPi2A; Slc17a2
Summary
Enables PDZ domain binding activity; identical protein binding activity; and sodium:phosphate symporter activity. Involved in several processes, including arsenate ion transmembrane transport; phosphate ion transport; and regulation of phosphate transport. Located in several cellular components, including apical plasma membrane; brush border membrane; and perinuclear region of cytoplasm. Biomarker of autosomal dominant polycystic kidney disease; chronic kidney disease (multiple); hyperthyroidism; hypophosphatemia; and hypothyroidism. Human ortholog(s) of this gene implicated in several diseases, including Fanconi syndrome (multiple); chronic kidney disease; hereditary hypophosphatemic rickets with hypercalciuria; hypophosphatemic nephrolithiasis/osteoporosis 1; and nephrolithiasis. Orthologous to human SLC34A1 (solute carrier family 34 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 4338.1) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Slc34a1 in Genome Data Viewer
Location:
17p14
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9224010..9238983, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9218876..9233852, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9747766..9762739, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene coagulation factor XII Neighboring gene profilin 3 Neighboring gene U6 spliceosomal RNA Neighboring gene regulator of G-protein signaling 14

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium:phosphate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium:phosphate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium:phosphate symporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sodium:phosphate symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables sodium:phosphate symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in arsenate ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within bone remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to parathyroid hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to phosphate starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to staurosporine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in dentinogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in gentamycin metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in glycoprotein metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in indole metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in inorganic diphosphate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular phosphate ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ossification IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphate ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphate ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sodium-dependent phosphate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sodium-dependent phosphate transport IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of sodium-dependent phosphate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to growth hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lead ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to magnesium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mercury ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to parathyroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to potassium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to sodium phosphate ISO
Inferred from Sequence Orthology
more info
 
involved_in response to thyroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sodium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium-dependent phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium-dependent phosphate transport IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in tricarboxylic acid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in brush border IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium-dependent phosphate transport protein 2A
Names
Na(+)-dependent phosphate cotransporter 2A
Na(+)/Pi cotransporter 2A
naPi-2a
sodium-phosphate co-transporter type II
sodium-phosphate transport protein 2A
sodium/phosphate cotransporter 2A
solute carrier family 17 (sodium/hydrogen exchanger) member 2
solute carrier family 34 (sodium phosphate), member 1
solute carrier family 34 (type II sodium/phosphate cotransporter), member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013030.2NP_037162.1  sodium-dependent phosphate transport protein 2A

    See identical proteins and their annotated locations for NP_037162.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q06496
    UniProtKB/TrEMBL
    A6KAT1, A6KAT2
    Related
    ENSRNOP00000031764.4, ENSRNOT00000033749.7
    Conserved Domains (1) summary
    TIGR01013
    Location:108588
    2a58; Phosphate:Na+ Symporter (PNaS) Family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    9224010..9238983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)