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GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 [ Homo sapiens (human) ]

Gene ID: 2555, updated on 2-Nov-2024

Summary

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Official Symbol
GABRA2provided by HGNC
Official Full Name
gamma-aminobutyric acid type A receptor subunit alpha2provided by HGNC
Primary source
HGNC:HGNC:4076
See related
Ensembl:ENSG00000151834 MIM:137140; AllianceGenome:HGNC:4076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEE78; EIEE78
Summary
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Biased expression in brain (RPKM 13.5), kidney (RPKM 1.1) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See GABRA2 in Genome Data Viewer
Location:
4p12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (46243548..46390300, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (46210399..46357479, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (46245565..46392317, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak5030 silencer Neighboring gene RN7SK pseudogene 199 Neighboring gene gamma-aminobutyric acid type A receptor subunit gamma1 Neighboring gene Sharpr-MPRA regulatory region 442 Neighboring gene RNA, U6 small nuclear 412, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr4:46687601-46687815 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:46725989-46726490 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:46726491-46726990 Neighboring gene Rac family small GTPase 1 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence. Lydall GJ, et al. Neurosci Lett, 2011 Aug 18. PMID 21683760
  2. Analysis of extreme drinking in patients with alcohol dependence using Pareto regression. Das S, et al. Stat Med, 2010 May 20. PMID 20225194, Free PMC Article
  3. Alternative splicing and promoter use in the human GABRA2 gene. Tian H, et al. Brain Res Mol Brain Res, 2005 Jun 13. PMID 15950776
  4. Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. Lappalainen J, et al. Alcohol Clin Exp Res, 2005 Apr. PMID 15834213
  5. GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. Pierucci-Lagha A, et al. Neuropsychopharmacology, 2005 Jun. PMID 15702134

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel variants in GABAA receptor subunits: A possible association with benzodiazepine resistance in patients with drug-resistant epilepsy.
    Title: Novel variants in GABA(A) receptor subunits: A possible association with benzodiazepine resistance in patients with drug-resistant epilepsy.
  2. Prospective DNA Methylation Analysis of the CpG GABRA2 Receptor Subunit in Alcohol Dependence during Detoxification.
    Title: Prospective DNA Methylation Analysis of the CpG GABRA2 Receptor Subunit in Alcohol Dependence during Detoxification.
  3. Gabra2 is a genetic modifier of Dravet syndrome in mice.
    Title: Gabra2 is a genetic modifier of Dravet syndrome in mice.
  4. Longitudinal Links between Adolescent and Peer Conduct Problems and Moderation by a Sensitivity Genetic Index.
    Title: Longitudinal Links between Adolescent and Peer Conduct Problems and Moderation by a Sensitivity Genetic Index.
  5. Gene expression meta-analysis reveals the down-regulation of three GABA receptor subunits in the superior temporal gyrus of patients with schizophrenia.
    Title: Gene expression meta-analysis reveals the down-regulation of three GABA receptor subunits in the superior temporal gyrus of patients with schizophrenia.
  6. Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse.
    Title: Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse.
  7. FRMD7 Mutations Disrupt the Interaction with GABRA2 and May Result in Infantile Nystagmus Syndrome.
    Title: FRMD7 Mutations Disrupt the Interaction with GABRA2 and May Result in Infantile Nystagmus Syndrome.
  8. The strongest association for alcohol use disorder (rs3756007) was located in GABRA2, the strongest association for antisocial behavior (rs11941860) was located in GABRG1, and the interaction term yielded top associations in GABRA2 (rs2119183) and the intergenic region between GABRA2 and GABRG1 (rs536599).
    Title: Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior.
  9. The GABRA2 p.T292K variant reduced channel expression and produced mutant channels that were tonically open, even in the absence of GABA.
    Title: De novo variants in GABRA2 and GABRA5 alter receptor function and contribute to early-onset epilepsy.
  10. To test an age-varying interaction between a single nucleotide polymorphism in the GABRA2 gene (rs279845) and a preventive intervention in predicting alcohol misuse in a longitudinal study of adolescents (ages 11-20). Intervention effects on adolescent alcohol misuse may differ by genotype, and evidence suggests that the interaction between GABRA2 and intervention effects on alcohol use may vary with age.
    Title: PROSPER Intervention Effects on Adolescents' Alcohol Misuse Vary by GABRA2 Genotype and Age.
Submit: New GeneRIF Correction See all GeneRIFs (91)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Alcohol dependence
MedGen: C0001973 OMIM: 103780 GeneReviews: Not available
Compare labs
Developmental and epileptic encephalopathy, 78
MedGen: C5231409 OMIM: 618557 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces mucus formation through the NACHRA7/GABRA2 pathway in normal human bronchial epithelial cells PubMed
env MUC5AC and GABRA2 are upregulated more strongly by HIV-1 X4- and X4/R5- than R5-tropic gp120 in normal human bronchial epithelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ97076

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA-gated chloride ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA-gated chloride ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables benzodiazepine receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamma-aminobutyric acid signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inhibitory synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inhibitory synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GABA-A receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of GABA-A receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in inhibitory synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-aminobutyric acid receptor subunit alpha-2
Names
GABA(A) receptor subunit alpha-2
GABAAR subunit alpha-2
gamma-aminobutyric acid type A receptor alpha2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012835.2 RefSeqGene

    Range
    4912..151492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000807.4 → NP_000798.2  gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor

    See identical proteins and their annotated locations for NP_000798.2

    Status: REVIEWED

    Source sequence(s)
    AB209295, AC095060, AC104072, AF086092, BX108394, DA778940, DB478542, DN991770
    Consensus CDS
    CCDS3471.1
    UniProtKB/Swiss-Prot
    A8K0U7, B7Z1H8, P47869, Q59G14
    UniProtKB/TrEMBL
    Q8TBI4
    Related
    ENSP00000371033.4, ENST00000381620.9
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 440
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  2. NM_001114175.3 → NP_001107647.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor

    See identical proteins and their annotated locations for NP_001107647.1

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS3471.1
    UniProtKB/Swiss-Prot
    A8K0U7, B7Z1H8, P47869, Q59G14
    UniProtKB/TrEMBL
    Q8TBI4
    Related
    ENSP00000348897.1, ENST00000356504.5
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 440
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  3. NM_001286827.3 → NP_001273756.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform b

    See identical proteins and their annotated locations for NP_001273756.1

    Status: REVIEWED

    Source sequence(s)
    AC095060, AC104072, AF086092, AK293466, BX108394, DA778940, DB478542, DN991770
    UniProtKB/Swiss-Prot
    P47869
    Conserved Domains (3) summary
    TIGR00860
    Location:31 → 445
    LIC; Cation transporter family protein
    cd03558
    Location:111 → 125
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:9 → 194
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

  4. NM_001330690.2 → NP_001317619.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS82921.1
    UniProtKB/TrEMBL
    E9PBQ7
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 500
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  5. NM_001377144.1 → NP_001364073.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS82921.1
    UniProtKB/TrEMBL
    E9PBQ7
    Related
    ENSP00000444409.2, ENST00000540012.5
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 500
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  6. NM_001377145.1 → NP_001364074.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS82921.1
    UniProtKB/TrEMBL
    E9PBQ7
    Related
    ENSP00000427603.1, ENST00000507069.5
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 500
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  7. NM_001377146.1 → NP_001364075.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS3471.1
    UniProtKB/Swiss-Prot
    A8K0U7, B7Z1H8, P47869, Q59G14
    UniProtKB/TrEMBL
    Q8TBI4
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 440
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  8. NM_001377147.1 → NP_001364076.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS3471.1
    UniProtKB/Swiss-Prot
    A8K0U7, B7Z1H8, P47869, Q59G14
    UniProtKB/TrEMBL
    Q8TBI4
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 440
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  9. NM_001377148.1 → NP_001364077.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS3471.1
    UniProtKB/Swiss-Prot
    A8K0U7, B7Z1H8, P47869, Q59G14
    UniProtKB/TrEMBL
    Q8TBI4
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 440
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  10. NM_001377149.1 → NP_001364078.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS3471.1
    UniProtKB/Swiss-Prot
    A8K0U7, B7Z1H8, P47869, Q59G14
    UniProtKB/TrEMBL
    Q8TBI4
    Related
    ENSP00000421300.1, ENST00000514090.5
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 440
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  11. NM_001377150.1 → NP_001364079.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS3471.1
    UniProtKB/Swiss-Prot
    A8K0U7, B7Z1H8, P47869, Q59G14
    UniProtKB/TrEMBL
    Q8TBI4
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 440
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  12. NM_001377151.1 → NP_001364080.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS3471.1
    UniProtKB/Swiss-Prot
    A8K0U7, B7Z1H8, P47869, Q59G14
    UniProtKB/TrEMBL
    Q8TBI4
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 440
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  13. NM_001377152.1 → NP_001364081.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Conserved Domains (3) summary
    TIGR00860
    Location:31 → 385
    LIC; Cation transporter family protein
    cd03558
    Location:111 → 125
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:12 → 194
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

  14. NM_001377153.1 → NP_001364082.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Conserved Domains (3) summary
    TIGR00860
    Location:31 → 385
    LIC; Cation transporter family protein
    cd03558
    Location:111 → 125
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:12 → 194
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

  15. NM_001377154.1 → NP_001364083.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Conserved Domains (3) summary
    TIGR00860
    Location:31 → 385
    LIC; Cation transporter family protein
    cd03558
    Location:111 → 125
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:12 → 194
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

  16. NM_001377155.1 → NP_001364084.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform e precursor

    Status: REVIEWED

    Source sequence(s)
    AC093745, AC095060, AC104072
    Consensus CDS
    CCDS93494.1
    UniProtKB/TrEMBL
    G5E9Z6, Q8TBI4
    Related
    ENSP00000423840.1, ENST00000515082.5
    Conserved Domains (2) summary
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)
    cd19052
    Location:252 → 337
    LGIC_TM_GABAAR_alpha; transmembrane domain of alpha subunits of type-A gamma-aminobutyric acid receptor (GABAAR)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    46243548..46390300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453967.2 → XP_024309735.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    E9PBQ7
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 500
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  2. XM_011513675.2 → XP_011511977.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_011511977.1

    UniProtKB/TrEMBL
    E9PBQ7
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 500
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  3. XM_024453964.2 → XP_024309732.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    E9PBQ7
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 500
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

  4. XM_024453966.2 → XP_024309734.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    E9PBQ7
    Conserved Domains (2) summary
    TIGR00860
    Location:25 → 500
    LIC; Cation transporter family protein
    cd19035
    Location:47 → 249
    LGIC_ECD_GABAAR_A2; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-2 (GABAAR-A2 or GABRA2)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    46210399..46357479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349539.1 → XP_054205514.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    E9PBQ7

  2. XM_054349537.1 → XP_054205512.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    E9PBQ7

  3. XM_054349536.1 → XP_054205511.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    E9PBQ7

  4. XM_054349538.1 → XP_054205513.1  gamma-aminobutyric acid receptor subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    E9PBQ7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47869.2 GenPept UniProtKB/Swiss-Prot:P47869

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