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Ttpa alpha tocopherol transfer protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 25571, updated on 28-Oct-2024

Summary

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Symbol
Ttpaprovided by RGD
Full Name
alpha tocopherol transfer proteinprovided by RGD
Primary source
RGD:3915
See related
EnsemblRapid:ENSRNOG00000007139 AllianceGenome:RGD:3915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TTP; alpha-TTP
Summary
Enables vitamin E binding activity. Involved in several processes, including intracellular pH reduction; negative regulation of epithelial cell apoptotic process; and response to pH. Located in late endosome. Biomarker of liver benign neoplasm. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward (RPKM 2733.5) See more
Orthologs
human mouse all
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Genomic context

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See Ttpa in Genome Data Viewer
Location:
5q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (38294415..38315471)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (33497537..33518936)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (34007926..34029315)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 13 Neighboring gene ATPase H+ transporting V0 subunit D2 Neighboring gene uncharacterized LOC134478943 Neighboring gene gamma-glutamyl hydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. pH-dependent translocation of alpha-tocopherol transfer protein (alpha-TTP) between hepatic cytosol and late endosomes. Horiguchi M, et al. Genes Cells, 2003 Oct. PMID 14531858
  2. Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol. Yoshida H, et al. J Lipid Res, 1992 Mar. PMID 1569384
  3. Primary structure of alpha-tocopherol transfer protein from rat liver. Homology with cellular retinaldehyde-binding protein. Sato Y, et al. J Biol Chem, 1993 Aug 25. PMID 8349655
  4. Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis. Wu CG, et al. Int J Cancer, 1997 May 16. PMID 9178827
  5. alpha-tocopherol transfer protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway. Arita M, et al. Proc Natl Acad Sci U S A, 1997 Nov 11. PMID 9356467, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The reduced expression of hepatic alpha-TTP and CYP4F2 genes probably leads to decreased plasma alpha-tocopherol levels and elevated alpha-tocopherol levels in the liver of streptozotocin rats.
    Title: α-Tocopherol status and altered expression of α-tocopherol-related proteins in streptozotocin-induced type 1 diabetes in rat models.
  2. Liver X receptor regulates alpha-TTP expression through direct interaction with the alpha-TTP gene promoter, and it modulates circulating alpha-tocopherol levels.
    Title: Liver X receptor up-regulates α-tocopherol transfer protein expression and α-tocopherol status.
  3. The Goto-Kakizaki (GK) rats showed an increase of the hepatic expression of the alpha-TTP gene as compared with ... controls. ... the increased hepatic alpha-TTP gene expression levels may influence plasma alpha-tocopherol levels in the diabetic animals.
    Title: α-Tocopherol status and expression of α-tocopherol transfer protein in type 2 diabetic Goto-Kakizaki rats.
  4. alpha-TTP protects against CQ toxicity by preventing CQ accumulation in acidic organelles through a mechanism distinct from vitamin E transport.
    Title: A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity.
  5. findings show that intracellular processing of tocopherol involves a functional interaction between TTP and an ABC-type transporter.
    Title: Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein.
  6. TTP transports alpha-TCP and oral administration of TTP compensates for TTP in TTP-deficient mice
    Title: Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables vitamin E binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables vitamin E binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables vitamin E binding IEA
Inferred from Electronic Annotation
more info
  
enables vitamin E binding ISO
Inferred from Sequence Orthology
more info
  
enables vitamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic placenta development ISO
Inferred from Sequence Orthology
more info
  
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in intermembrane lipid transfer ISO
Inferred from Sequence Orthology
more info
  
involved_in intermembrane lipid transfer ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular pH reduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of epithelial cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of establishment of blood-brain barrier IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of establishment of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to pH IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin E metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vitamin E metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vitamin E metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin E metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vitamin transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vitamin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-tocopherol transfer protein
Names
Tocopherol transfer protein alpha
alpha-tocopherol transfer protein-like
tocopherol (alpha) transfer protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429356.1 → NP_001416285.1  alpha-tocopherol transfer protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IID5

  2. NM_001429357.1 → NP_001416286.1  alpha-tocopherol transfer protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IID5

  3. NM_013048.4 → NP_037180.1  alpha-tocopherol transfer protein isoform 1

    See identical proteins and their annotated locations for NP_037180.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P41034
    UniProtKB/TrEMBL
    A0A8L2Q527, A6IID4
    Related
    ENSRNOP00000009611.3, ENSRNOT00000009611.4
    Conserved Domains (2) summary
    smart01100
    Location:25 → 73
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:99 → 248
    CRAL_TRIO; CRAL/TRIO domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    38294415..38315471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109317.2 → XP_038965245.1  alpha-tocopherol transfer protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6GHG2
    Conserved Domains (1) summary
    pfam00650
    Location:73 → 222
    CRAL_TRIO; CRAL/TRIO domain

  2. XM_017593164.2 → XP_017448653.1  alpha-tocopherol transfer protein isoform X4

    Conserved Domains (1) summary
    pfam00650
    Location:30 → 179
    CRAL_TRIO; CRAL/TRIO domain

  3. XM_063287196.1 → XP_063143266.1  alpha-tocopherol transfer protein isoform X2

    Related
    ENSRNOP00000107412.1, ENSRNOT00000149952.1

  4. XM_039109318.2 → XP_038965246.1  alpha-tocopherol transfer protein isoform X4

    Conserved Domains (1) summary
    pfam00650
    Location:30 → 179
    CRAL_TRIO; CRAL/TRIO domain

  5. XM_017593163.3 → XP_017448652.2  alpha-tocopherol transfer protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6GHG2
    Conserved Domains (1) summary
    pfam00650
    Location:90 → 239
    CRAL_TRIO; CRAL/TRIO domain

  6. XM_039109319.2 → XP_038965247.1  alpha-tocopherol transfer protein isoform X5

    Conserved Domains (1) summary
    pfam00650
    Location:25 → 151
    CRAL_TRIO; CRAL/TRIO domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41034.1 GenPept UniProtKB/Swiss-Prot:P41034

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