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Rasa2 RAS p21 protein activator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25597, updated on 28-Oct-2024

Summary

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Official Symbol
Rasa2provided by RGD
Official Full Name
RAS p21 protein activator 2provided by RGD
Primary source
RGD:3538
See related
EnsemblRapid:ENSRNOG00000011909 AllianceGenome:RGD:3538
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GAP1M
Summary
Enables GTPase activator activity. Predicted to be involved in intracellular signal transduction and negative regulation of Ras protein signal transduction. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human RASA2 (RAS p21 protein activator 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 146.3), Kidney (RPKM 143.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rasa2 in Genome Data Viewer
Location:
8q31
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (105996797..106116285, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (97119983..97236687, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (104417827..104542313, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094236 Neighboring gene leucine rich repeat containing 78 Neighboring gene uncharacterized LOC120094237 Neighboring gene peptidyl-prolyl cis-trans isomerase D pseudogene Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene uncharacterized LOC100909637 Neighboring gene uncharacterized LOC134480088

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Next-generation sequencing identifies rare variants associated with Noonan syndrome. Chen PC, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049390, Free PMC Article
  2. Purification of a novel ras GTPase-activating protein from rat brain. Maekawa M, et al. J Biol Chem, 1993 Oct 25. PMID 8226805
  3. A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions. Maekawa M, et al. Mol Cell Biol, 1994 Oct. PMID 7935405, Free PMC Article
  4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105724.1 → NP_001099194.1  ras GTPase-activating protein 2

    See identical proteins and their annotated locations for NP_001099194.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/Swiss-Prot
    Q63713
    UniProtKB/TrEMBL
    A6I283
    Related
    ENSRNOP00000016327.4, ENSRNOT00000016327.7
    Conserved Domains (7) summary
    smart00107
    Location:706 → 741
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:171 → 313
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:38 → 158
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    smart00323
    Location:300 → 641
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13370
    Location:589 → 721
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    pfam00169
    Location:606 → 704
    PH; PH domain
    cl02569
    Location:322 → 592
    RasGAP; Ras GTPase Activating Domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    105996797..106116285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080892.2 → XP_038936820.1  ras GTPase-activating protein 2 isoform X1

    Conserved Domains (5) summary
    smart00107
    Location:649 → 684
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114 → 256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532 → 664
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265 → 535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1 → 101
    C2; C2 domain

  2. XM_063264951.1 → XP_063121021.1  ras GTPase-activating protein 2 isoform X2

  3. XM_063264952.1 → XP_063121022.1  ras GTPase-activating protein 2 isoform X3

RNA

  1. XR_010053933.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63713.1 GenPept UniProtKB/Swiss-Prot:Q63713

Gene LinkOut

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