Lep leptin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25608, updated on 2-Nov-2024

Summary

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Official Symbol: Lepprovided by RGD
Official Full Name: leptinprovided by RGD
Primary source: RGD:3000
See related: EnsemblRapid:ENSRNOG00000045797 AllianceGenome:RGD:3000
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: OB; obese
Summary: Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and regulation of protein metabolic process. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); and short bowel syndrome. Biomarker of several diseases, including Huntington's disease; alcohol dependence; lipid metabolism disorder (multiple); liver disease (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 108.2), Thymus (RPKM 61.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Lep in Genome Data Viewer

Location:: 4q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (58626529..58640663)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (57661127..57675262)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (56337695..56351818)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of intracerebroventricular leptin and orexin-A on the baroreflex control of renal sympathetic nerve activity in conscious rats fed a normal or high-fat diet.
Title: Effects of intracerebroventricular leptin and orexin-A on the baroreflex control of renal sympathetic nerve activity in conscious rats fed a normal or high-fat diet.
Baroreflex afferent function is a part of insights of Leptin-mediated blood pressure reduction and Leptin-resistance hypertension.
Title: Baroreflex afferent function is a part of insights of Leptin-mediated blood pressure reduction and Leptin-resistance hypertension.
Leptin decreases the transcription of BKCa channels and Gs to Gi protein-ratio in late pregnant rat uterus.
Title: Leptin decreases the transcription of BK(Ca) channels and Gs to Gi protein-ratio in late pregnant rat uterus.
Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats.
Title: Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats.
The Postnatal Leptin Surge Supports Immune Cell Function in Rats.
Title: The Postnatal Leptin Surge Supports Immune Cell Function in Rats.
Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy.
Title: Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D(3) is mediated by inhibition of chaperone-mediated autophagy.
Leptin Induces Apoptotic and Pyroptotic Cell Death via NLRP3 Inflammasome Activation in Rat Hepatocytes.
Title: Leptin Induces Apoptotic and Pyroptotic Cell Death via NLRP3 Inflammasome Activation in Rat Hepatocytes.
Differences between rats and mice in the leptin action on the paraventricular nucleus of the hypothalamus: Implications for the regulation of the hypothalamic-pituitary-thyroid axis.
Title: Differences between rats and mice in the leptin action on the paraventricular nucleus of the hypothalamus: Implications for the regulation of the hypothalamic-pituitary-thyroid axis.
High Maternal Omega-3 Supplementation Dysregulates Body Weight and Leptin in Newborn Male and Female Rats: Implications for Hypothalamic Developmental Programming.
Title: High Maternal Omega-3 Supplementation Dysregulates Body Weight and Leptin in Newborn Male and Female Rats: Implications for Hypothalamic Developmental Programming.
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring.
Title: Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring.

Submit: New GeneRIF Correction See all GeneRIFs (381)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC21729P1 (e-PCR)
- UniSTS:143768

Lep (e-PCR), detects polymorphism
- UniSTS:143768

Lep (e-PCR), detects polymorphism
- UniSTS:143770

LEP-3 (e-PCR)
- UniSTS:253879

RH94808 (e-PCR)
- UniSTS:120054

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables leptin receptor binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of protein kinase C activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase C activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in adult feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in adult feeding behavior	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in bone growth	ISO Inferred from Sequence Orthology more info
involved_in bone growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone mineralization involved in bone maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in cardiac muscle hypertrophy	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leptin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within central nervous system neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within eating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within elastin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in energy reserve metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in energy reserve metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hormone metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in intestinal absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in leptin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose import	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of appetite by leptin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of appetite by leptin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cartilage development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glucagon secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glutamine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	IDA Inferred from Direct Assay more info	PubMed
involved_in ovulation from ovarian follicle	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytokine production	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of developmental growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of follicle-stimulating hormone secretion	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of hepatic stellate cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of luteinizing hormone secretion	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein modification process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of brown fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipoprotein lipid oxidation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of natural killer cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of natural killer cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of nitric-oxide synthase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in sexual reproduction	ISO Inferred from Sequence Orthology more info
involved_in tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leptin

Names: obesity factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.