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Cma1 chymase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25627, updated on 2-Nov-2024

Summary

Official Symbol
Cma1provided by RGD
Official Full Name
chymase 1provided by RGD
Primary source
RGD:2365
See related
EnsemblRapid:ENSRNOG00000020563 AllianceGenome:RGD:2365
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MCP3P; Mcpt5
Summary
Enables peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to glucose stimulus; midbrain development; and positive regulation of angiogenesis. Located in extracellular region. Biomarker of renovascular hypertension. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; hypertrophic cardiomyopathy; and sarcoidosis. Orthologous to human CMA1 (chymase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 66.2), Thymus (RPKM 37.9) and 7 other tissues See more
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Genomic context

See Cma1 in Genome Data Viewer
Location:
15p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33387351..33390133, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29417451..29420233, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34601037..34603819, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 50 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene mast cell protease 1-like Neighboring gene mast cell protease 4-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables peptide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in basement membrane disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cytokine precursor processing ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in midbrain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in peptide metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
chymase
Names
alpha-chymase
chymase 1, mast cell
mast cell protease 3
mast cell protease 5
mast cell protease III
rMCP-3
rMCP-5
rMCP-III
NP_037224.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013092.2NP_037224.1  chymase precursor

    See identical proteins and their annotated locations for NP_037224.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    P50339, Q9R2C8
    UniProtKB/TrEMBL
    A6KH67
    Related
    ENSRNOP00000061330.2, ENSRNOT00000067539.4
    Conserved Domains (2) summary
    smart00020
    Location:21240
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:22243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    33387351..33390133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)