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Dgkg diacylglycerol kinase, gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 25666, updated on 2-Nov-2024

Summary

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Official Symbol
Dgkgprovided by RGD
Official Full Name
diacylglycerol kinase, gammaprovided by RGD
Primary source
RGD:2499
See related
EnsemblRapid:ENSRNOG00000001796 AllianceGenome:RGD:2499
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dagk3; DGKIII; DGK-III
Summary
Enables ATP-dependent diacylglycerol kinase activity. Involved in neuron development. Located in membrane. Orthologous to human DGKG (diacylglycerol kinase gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 253.6), Brain (RPKM 95.7) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Dgkg in Genome Data Viewer
Location:
11q23
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91888957..92083715)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (78384212..78579158)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (81971585..82165111)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911962 Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene 1 Neighboring gene uncharacterized LOC102552590 Neighboring gene uncharacterized LOC120095691 Neighboring gene ETS variant transcription factor 5 Neighboring gene transfer RNA methionine (anticodon CAU) 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cellular expression and subcellular localization of diacylglycerol kinase γ in rat brain. Hozumi Y, et al. Biomed Res, 2021. PMID 33563877
  2. Diacylglycerol kinase γ regulates antigen-induced mast cell degranulation by mediating Ca(2+) influxes. Sakuma M, et al. Biochem Biophys Res Commun, 2014 Mar 7. PMID 24513282
  3. Cloning and expression of a cytoskeleton-associated diacylglycerol kinase that is dominantly expressed in cerebellum. Goto K, et al. Proc Natl Acad Sci U S A, 1994 Dec 20. PMID 7809169, Free PMC Article
  4. Immunocytochemical localization of a neuron-specific diacylglycerol kinase beta and gamma in the developing rat brain. Adachi N, et al. Brain Res Mol Brain Res, 2005 Oct 3. PMID 16019106
  5. Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma. Yamaguchi Y, et al. J Biol Chem, 2006 Oct 20. PMID 16905533

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cellular expression and subcellular localization of diacylglycerol kinase gamma in rat brain.
    Title: Cellular expression and subcellular localization of diacylglycerol kinase γ in rat brain.
  2. Knockdown of Dgkg, but not DGK-alpha, inhibited degranulation in mast cells.
    Title: Diacylglycerol kinase γ regulates antigen-induced mast cell degranulation by mediating Ca(2+) influxes.
  3. In brain, DGKgamma showed sustained expression throughout the postnatal developmental periods. And In the hippocampal pyramidal cell, Dgkg localized in the cytosol.
    Title: Immunocytochemical localization of a neuron-specific diacylglycerol kinase beta and gamma in the developing rat brain.
  4. localization and activation of the functionally correlated kinases, gammaPKC and DGKgamma, are spatio-temporally orchestrated by their direct association and phosphorylation, contributing to subtype-specific regulation of DGKgamma and DAG signaling
    Title: Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in diacylglycerol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycerolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of phospholipase C/protein kinase C signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
diacylglycerol kinase gamma
Names
88 kDa diacylglycerol kinase
DAG kinase gamma
DGK-gamma
Diacylglycerol kinase 3 (gamma)
diglyceride kinase gamma
NP_037258.1
XP_006248600.1
XP_006248602.1
XP_038943971.1
XP_038943972.1
XP_063126382.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013126.2 → NP_037258.1  diacylglycerol kinase gamma

    See identical proteins and their annotated locations for NP_037258.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    P49620
    UniProtKB/TrEMBL
    A6JS57
    Related
    ENSRNOP00000102537.1, ENSRNOT00000132290.1
    Conserved Domains (8) summary
    smart00109
    Location:333 → 380
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00045
    Location:575 → 749
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:433 → 554
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:433 → 759
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00029
    Location:269 → 318
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:176 → 245
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:177 → 241
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:5 → 172
    DAG_kinase_N; Diacylglycerol kinase N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    91888957..92083715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270312.1 → XP_063126382.1  diacylglycerol kinase gamma isoform X2

    Related
    ENSRNOP00000002452.6, ENSRNOT00000002452.7

  2. XM_006248538.5 → XP_006248600.1  diacylglycerol kinase gamma isoform X1

    UniProtKB/TrEMBL
    A0A8I6A589, A6JS57
    Related
    ENSRNOP00000088510.1, ENSRNOT00000105472.2
    Conserved Domains (7) summary
    smart00045
    Location:536 → 710
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:394 → 515
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:394 → 720
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00029
    Location:269 → 318
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:176 → 245
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:177 → 241
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:5 → 172
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  3. XM_006248540.5 → XP_006248602.1  diacylglycerol kinase gamma isoform X3

    Conserved Domains (7) summary
    smart00109
    Location:333 → 380
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00046
    Location:433 → 554
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:269 → 318
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:176 → 245
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:177 → 241
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:5 → 172
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cl02440
    Location:575 → 607
    DAGK_acc; Diacylglycerol kinase accessory domain

  4. XM_039088043.2 → XP_038943971.1  diacylglycerol kinase gamma isoform X4

    Conserved Domains (4) summary
    smart00045
    Location:408 → 582
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:266 → 387
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:9 → 78
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00040
    Location:85 → 158
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  5. XM_039088044.2 → XP_038943972.1  diacylglycerol kinase gamma isoform X4

    Conserved Domains (4) summary
    smart00045
    Location:408 → 582
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:266 → 387
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:9 → 78
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00040
    Location:85 → 158
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

RNA

  1. XR_005490982.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49620.1 GenPept UniProtKB/Swiss-Prot:P49620

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